1mdz: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of ArnB aminotransferase with cycloserine and pyridoxal 5' phosphate== | ==Crystal structure of ArnB aminotransferase with cycloserine and pyridoxal 5' phosphate== | ||
<StructureSection load='1mdz' size='340' side='right' caption='[[1mdz]], [[Resolution|resolution]] 2.07Å' scene=''> | <StructureSection load='1mdz' size='340' side='right'caption='[[1mdz]], [[Resolution|resolution]] 2.07Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1mdz]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1mdz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MDZ FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCS:D-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-N,O-CYCLOSERYLAMIDE'>DCS</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCS:D-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-N,O-CYCLOSERYLAMIDE'>DCS</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mdz OCA], [https://pdbe.org/1mdz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mdz RCSB], [https://www.ebi.ac.uk/pdbsum/1mdz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mdz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ARNB_SALTY ARNB_SALTY] Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity).[HAMAP-Rule:MF_01167] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 15: | Line 15: | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/1mdz_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/1mdz_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| Line 31: | Line 31: | ||
==See Also== | ==See Also== | ||
*[[Aminotransferase|Aminotransferase]] | *[[Aminotransferase 3D structures|Aminotransferase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Badger | [[Category: Salmonella enterica subsp. enterica serovar Typhimurium]] | ||
[[Category: Buchanan | [[Category: Badger J]] | ||
[[Category: Buchanan | [[Category: Buchanan MD]] | ||
[[Category: Christopher | [[Category: Buchanan SG]] | ||
[[Category: Gajiwala | [[Category: Christopher JA]] | ||
[[Category: Hendle | [[Category: Gajiwala KS]] | ||
[[Category: Muller-Dieckmann | [[Category: Hendle J]] | ||
[[Category: Newman | [[Category: Muller-Dieckmann H-J]] | ||
[[Category: Noland | [[Category: Newman JM]] | ||
[[Category: Rutter | [[Category: Noland BW]] | ||
[[Category: Sanderson | [[Category: Rutter ME]] | ||
[[Category: Sauder | [[Category: Sanderson WE]] | ||
[[Category: Tresser | [[Category: Sauder JM]] | ||
[[Category: Wright | [[Category: Tresser J]] | ||
[[Category: Wright T]] | |||
Latest revision as of 22:07, 26 March 2025
Crystal structure of ArnB aminotransferase with cycloserine and pyridoxal 5' phosphate
| ||||||||||||
