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==Crystal structures of holo and Cu-deficient Cu/ZnSOD from the silkworm Bombyx mori and the implications in Amyotrophic lateral sclerosis==
==Crystal structures of holo and Cu-deficient Cu/ZnSOD from the silkworm Bombyx mori and the implications in Amyotrophic lateral sclerosis==
<StructureSection load='3l9e' size='340' side='right' caption='[[3l9e]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='3l9e' size='340' side='right'caption='[[3l9e]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3l9e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bommo Bommo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L9E FirstGlance]. <br>
<table><tr><td colspan='2'>[[3l9e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L9E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3l9y|3l9y]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SOD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7091 BOMMO])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l9e OCA], [https://pdbe.org/3l9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l9e RCSB], [https://www.ebi.ac.uk/pdbsum/3l9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l9e ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l9e OCA], [http://pdbe.org/3l9e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l9e RCSB], [http://www.ebi.ac.uk/pdbsum/3l9e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l9e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SODC_BOMMO SODC_BOMMO]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[UniProtKB:P00441]  
[https://www.uniprot.org/uniprot/SODC_BOMMO SODC_BOMMO] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[UniProtKB:P00441]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l9/3l9e_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l9/3l9e_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[Superoxide Dismutase|Superoxide Dismutase]]
*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bommo]]
[[Category: Bombyx mori]]
[[Category: Superoxide dismutase]]
[[Category: Large Structures]]
[[Category: Chen, Y]]
[[Category: Chen Y]]
[[Category: He, Y X]]
[[Category: He Y-X]]
[[Category: Li, W F]]
[[Category: Li W-F]]
[[Category: Teng, Y B]]
[[Category: Teng Y-B]]
[[Category: Yan, L F]]
[[Category: Yan L-F]]
[[Category: Yu, J]]
[[Category: Yu J]]
[[Category: Zhang, G Z]]
[[Category: Zhang G-Z]]
[[Category: Zhang, N N]]
[[Category: Zhang N-N]]
[[Category: Zhao, F]]
[[Category: Zhao F]]
[[Category: Zhou, C Z]]
[[Category: Zhou C-Z]]
[[Category: Antioxidant]]
[[Category: Cytoplasm]]
[[Category: Disulfide bond]]
[[Category: Greek-key-barrel]]
[[Category: Metal-binding]]
[[Category: Oxidoreductase]]
[[Category: Zinc]]