Rhodopsin Structure and Function: Difference between revisions
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<StructureSection load='1jfp' size='340' side='right' caption=' | <StructureSection load='1jfp' size='340' side='right' caption='Bovine rhodopsin complex with retinal (PDB code [[1jfp]])' scene=''> | ||
==Rhodopsin== | ==Rhodopsin== | ||
Rhodopsin is a member of the G-protein coupled receptor (GPCR) family. Rhodopsin is the | '''Rhodopsin''' is a member of the G-protein coupled receptor (GPCR) family. Rhodopsin is the | ||
common GPCR structure used to understand functionality of G-protein coupled receptors. | common GPCR structure used to understand functionality of G-protein coupled receptors. | ||
Rhodopsin is commonly found in the photoreceptors in the retina, specifically in the rod | Rhodopsin is commonly found in the photoreceptors in the retina, specifically in the rod | ||
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<scene name='77/778331/Rhodopsin_and_ligand/1'>Rhodopsin and Ligand</scene> This is rhodopsin with 11-cis retinal bound. After 11-cis retinal becomes activated and becomes all-trans, rhodopsin undergoes the conformational change to become metarhodopsin I and then metarhodopsin II which is the fully active form of rhodopsin. Metarhodopsin II then associates with the G protein transducin and the signal cascade can continue. | <scene name='77/778331/Rhodopsin_and_ligand/1'>Rhodopsin and Ligand</scene> This is rhodopsin with 11-cis retinal bound. After 11-cis retinal becomes activated and becomes all-trans, rhodopsin undergoes the conformational change to become metarhodopsin I and then metarhodopsin II which is the fully active form of rhodopsin. Metarhodopsin II then associates with the G protein transducin and the signal cascade can continue. | ||
See also: | |||
*[[Receptor]] | |||
*[[Transmembrane (cell surface) receptors]] | |||
*[[G protein-coupled receptors]] | |||
