6n5z: Difference between revisions

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'''Unreleased structure'''


The entry 6n5z is ON HOLD  until Paper Publication
==Crystal structure of the SNX5 PX domain in complex with the Sema4C==
<StructureSection load='6n5z' size='340' side='right'caption='[[6n5z]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6n5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N5Z FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n5z OCA], [https://pdbe.org/6n5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n5z RCSB], [https://www.ebi.ac.uk/pdbsum/6n5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n5z ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNX5_HUMAN SNX5_HUMAN] May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation.<ref>PMID:18854019</ref> <ref>PMID:21048941</ref> [https://www.uniprot.org/uniprot/SEM4C_HUMAN SEM4C_HUMAN] Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.<ref>PMID:17498836</ref>


Authors: Collins, B., Paul, B., Weeratunga, S.
==See Also==
 
*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
Description: Crystal structure of the SNX5 PX domain in complex with the Sema4C
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Weeratunga, S]]
__TOC__
[[Category: Collins, B]]
</StructureSection>
[[Category: Paul, B]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Collins B]]
[[Category: Paul B]]
[[Category: Weeratunga S]]
Retrieved from "https://proteopedia.org/6n5z"