6nl4: Difference between revisions
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==Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with gemcitabine== | |||
<StructureSection load='6nl4' size='340' side='right'caption='[[6nl4]], [[Resolution|resolution]] 1.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6nl4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NL4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.991Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GEO:GEMCITABINE'>GEO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nl4 OCA], [https://pdbe.org/6nl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nl4 RCSB], [https://www.ebi.ac.uk/pdbsum/6nl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nl4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BIOD_MYCTU BIOD_MYCTU] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.<ref>PMID:20565114</ref> | |||
==See Also== | |||
*[[Dethiobiotin synthetase 3D structures|Dethiobiotin synthetase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Bruning | </StructureSection> | ||
[[Category: Thompson | [[Category: Large Structures]] | ||
[[Category: Wegener | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: Bruning JB]] | |||
[[Category: Polyak SW]] | |||
[[Category: Thompson AP]] | |||
[[Category: Wegener KL]] | |||
Latest revision as of 14:48, 13 March 2024
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with gemcitabine
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