6nrr: Difference between revisions
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New page: '''Unreleased structure''' The entry 6nrr is ON HOLD Authors: Cheng, S., Park, Y.J., Kurleto, J.D., Ozkan, E. Description: Crystal structure of Dpr11 IG1 bound to DIP-gamma IG+IG2 [[Ca... |
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==Crystal structure of Dpr11 IG1 bound to DIP-gamma IG+IG2== | |||
<StructureSection load='6nrr' size='340' side='right'caption='[[6nrr]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6nrr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NRR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nrr OCA], [https://pdbe.org/6nrr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nrr RCSB], [https://www.ebi.ac.uk/pdbsum/6nrr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nrr ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q8MRE6_DROME Q8MRE6_DROME] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
In stereotyped neuronal networks, synaptic connectivity is dictated by cell surface proteins, which assign unique identities to neurons, and physically mediate axon guidance and synapse targeting. We recently identified two groups of immunoglobulin superfamily proteins in Drosophila, Dprs and DIPs, as strong candidates for synapse targeting functions. Here, we uncover the molecular basis of specificity in Dpr-DIP mediated cellular adhesions and neuronal connectivity. First, we present five crystal structures of Dpr-DIP and DIP-DIP complexes, highlighting the evolutionary and structural origins of diversification in Dpr and DIP proteins and their interactions. We further show that structures can be used to rationally engineer receptors with novel specificities or modified affinities, which can be used to study specific circuits that require Dpr-DIP interactions to help establish connectivity. We investigate one pair, engineered Dpr10 and DIP-alpha, for function in the neuromuscular circuit in flies, and reveal roles for homophilic and heterophilic binding in wiring. | |||
Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila.,Cheng S, Ashley J, Kurleto JD, Lobb-Rabe M, Park YJ, Carrillo RA, Ozkan E Elife. 2019 Jan 28;8. pii: 41028. doi: 10.7554/eLife.41028. PMID:30688651<ref>PMID:30688651</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 6nrr" style="background-color:#fffaf0;"></div> | ||
[[Category: Cheng | == References == | ||
[[Category: Kurleto | <references/> | ||
[[Category: Park | __TOC__ | ||
</StructureSection> | |||
[[Category: Drosophila melanogaster]] | |||
[[Category: Large Structures]] | |||
[[Category: Cheng S]] | |||
[[Category: Kurleto JD]] | |||
[[Category: Ozkan E]] | |||
[[Category: Park YJ]] | |||
Latest revision as of 06:58, 11 October 2023
Crystal structure of Dpr11 IG1 bound to DIP-gamma IG+IG2
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