6qh4: Difference between revisions
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New page: '''Unreleased structure''' The entry 6qh4 is ON HOLD Authors: Bailey, H.J., Chaikuid, A., Krysztofinska, E., Froese, D.S., Sorrell, F.J., Diaz-Saez, L., Kennedy, E., Edwards, A.M., Boun... |
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==Crystal structure of human Methylmalonyl-CoA epimerase (MCEE) p.Arg143Cys variant== | |||
<StructureSection load='6qh4' size='340' side='right'caption='[[6qh4]], [[Resolution|resolution]] 1.92Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6qh4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QH4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.922Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr> | ||
[[Category: Bailey | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qh4 OCA], [https://pdbe.org/6qh4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qh4 RCSB], [https://www.ebi.ac.uk/pdbsum/6qh4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qh4 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/MCEE_HUMAN MCEE_HUMAN] Vitamin B12-unresponsive methylmalonic acidemia. Methylmalonyl-CoA epimerase deficiency (MCEED) [MIM:[https://omim.org/entry/251120 251120]: Autosomal recessive inborn error of amino acid metabolism, involving valine, threonine, isoleucine and methionine. This organic aciduria may present in the neonatal period with life-threatening metabolic acidosis, hyperammonemia, feeding difficulties, pancytopenia and coma. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:16752391</ref> | ||
[[Category: Edwards | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/MCEE_HUMAN MCEE_HUMAN] | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bailey HJ]] | |||
[[Category: Bountra C]] | |||
[[Category: Chaikuid A]] | |||
[[Category: Diaz-Saez L]] | |||
[[Category: Edwards AM]] | |||
[[Category: Froese DS]] | |||
[[Category: Kennedy E]] | |||
[[Category: Krysztofinska E]] | |||
[[Category: Sorrell FJ]] | |||
[[Category: Yue WW]] | |||
Latest revision as of 12:00, 24 January 2024
Crystal structure of human Methylmalonyl-CoA epimerase (MCEE) p.Arg143Cys variant
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