6qil: Difference between revisions
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New page: '''Unreleased structure''' The entry 6qil is ON HOLD until Paper Publication Authors: Shaanan, B., Kutnowski, N. Description: The complex structure of hsRosR-S1 (VNG0258H/RosR-S1) [[Ca... |
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The | ==The complex structure of hsRosR-S1 (VNG0258H/RosR-S1)== | ||
<StructureSection load='6qil' size='340' side='right'caption='[[6qil]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6qil]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Halobacterium_salinarum_NRC-1 Halobacterium salinarum NRC-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QIL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qil OCA], [https://pdbe.org/6qil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qil RCSB], [https://www.ebi.ac.uk/pdbsum/6qil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qil ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q9HSF4_HALSA Q9HSF4_HALSA] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Interactions between proteins and DNA are crucial for all biological systems. Many studies have shown the dependence of protein-DNA interactions on the surrounding salt concentration. How these interactions are maintained in the hypersaline environments that halophiles inhabit remains puzzling. Towards solving this enigma, we identified the DNA motif recognized by the Halobactrium salinarum ROS-dependent transcription factor (hsRosR), determined the structure of several hsRosR-DNA complexes and investigated the DNA-binding process under extreme high-salt conditions. The picture that emerges from this work contributes to our understanding of the principles underlying the interplay between electrostatic interactions and salt-mediated protein-DNA interactions in an ionic environment characterized by molar salt concentrations. | |||
Specificity of protein-DNA interactions in hypersaline environment: structural studies on complexes of Halobacterium salinarum oxidative stress-dependent protein hsRosR.,Kutnowski N, Shmulevich F, Davidov G, Shahar A, Bar-Zvi D, Eichler J, Zarivach R, Shaanan B Nucleic Acids Res. 2019 Jul 16. pii: 5532612. doi: 10.1093/nar/gkz604. PMID:31310308<ref>PMID:31310308</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Kutnowski | <div class="pdbe-citations 6qil" style="background-color:#fffaf0;"></div> | ||
[[Category: Shaanan | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Halobacterium salinarum NRC-1]] | |||
[[Category: Large Structures]] | |||
[[Category: Kutnowski N]] | |||
[[Category: Shaanan B]] | |||
