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==Crystal structure of the T27A mutant of human alpha defensin HNP4.==
==Crystal structure of the T27A mutant of human alpha defensin HNP4.==
<StructureSection load='6dmq' size='340' side='right' caption='[[6dmq]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='6dmq' size='340' side='right'caption='[[6dmq]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6dmq]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DMQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DMQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[6dmq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DMQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dmq OCA], [http://pdbe.org/6dmq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dmq RCSB], [http://www.ebi.ac.uk/pdbsum/6dmq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dmq ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dmq OCA], [https://pdbe.org/6dmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dmq RCSB], [https://www.ebi.ac.uk/pdbsum/6dmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dmq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DEF4_HUMAN DEF4_HUMAN]] Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.<ref>PMID:15616305</ref> <ref>PMID:15620707</ref>
[https://www.uniprot.org/uniprot/DEF4_HUMAN DEF4_HUMAN] Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.<ref>PMID:15616305</ref> <ref>PMID:15620707</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6dmq" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6dmq" style="background-color:#fffaf0;"></div>
==See Also==
*[[Defensin 3D structures|Defensin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Gohain, N]]
[[Category: Homo sapiens]]
[[Category: Pazgier, M]]
[[Category: Large Structures]]
[[Category: Tolbert, W D]]
[[Category: Gohain N]]
[[Category: Antimicrobial peptide]]
[[Category: Pazgier M]]
[[Category: Antimicrobial protein]]
[[Category: Tolbert WD]]
[[Category: Human alpha-defensin]]
Retrieved from "https://proteopedia.org/6dmq"