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==A comparative study of uracil DNA glycosylases from human and herpes simplex virus type 1==
==A comparative study of uracil DNA glycosylases from human and herpes simplex virus type 1==
<StructureSection load='2c53' size='340' side='right' caption='[[2c53]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2c53' size='340' side='right'caption='[[2c53]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2c53]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C53 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C53 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2c53]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C53 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUR:2-DEOXYURIDINE'>DUR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lau|1lau]], [[1udg|1udg]], [[1udh|1udh]], [[1udi|1udi]], [[2c56|2c56]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUR:2-DEOXYURIDINE'>DUR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_nucleosidase Uridine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c53 OCA], [https://pdbe.org/2c53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c53 RCSB], [https://www.ebi.ac.uk/pdbsum/2c53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c53 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c53 OCA], [http://pdbe.org/2c53 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c53 RCSB], [http://www.ebi.ac.uk/pdbsum/2c53 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c53 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UNG_HHV11 UNG_HHV11]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosine. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly, in terminally differentiated neurons which lack DNA repair enzymes.<ref>PMID:7552746</ref> <ref>PMID:16306042</ref>
[https://www.uniprot.org/uniprot/UNG_HHV11 UNG_HHV11] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosine. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly, in terminally differentiated neurons which lack DNA repair enzymes.<ref>PMID:7552746</ref> <ref>PMID:16306042</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[DNA glycosylase|DNA glycosylase]]
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hhv-1]]
[[Category: Human alphaherpesvirus 1]]
[[Category: Uridine nucleosidase]]
[[Category: Large Structures]]
[[Category: Baldwin, G S]]
[[Category: Baldwin GS]]
[[Category: Bellmy, S R.W]]
[[Category: Bellmy SRW]]
[[Category: Carpenter, E P]]
[[Category: Carpenter EP]]
[[Category: Krusong, K]]
[[Category: Krusong K]]
[[Category: Savva, R]]
[[Category: Savva R]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: Glycosidase]]
[[Category: Hydrolase]]
[[Category: Uracil dna glycosylase]]
Retrieved from "https://proteopedia.org/2c53"