2ens: Difference between revisions
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New page: left|200px {{Structure |PDB= 2ens |SIZE=350|CAPTION= <scene name='initialview01'>2ens</scene> |SITE= |LIGAND= |ACTIVITY= |GENE= AGER ([http://www.ncbi.nlm.nih.gov/T... |
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==Solution structure of the third ig-like domain from human Advanced glycosylation end product-specific receptor== | |||
<StructureSection load='2ens' size='340' side='right'caption='[[2ens]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2ens]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ENS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ENS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ens FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ens OCA], [https://pdbe.org/2ens PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ens RCSB], [https://www.ebi.ac.uk/pdbsum/2ens PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ens ProSAT], [https://www.topsan.org/Proteins/RSGI/2ens TOPSAN]</span></td></tr> | |||
</table> | |||
| | == Function == | ||
[https://www.uniprot.org/uniprot/RAGE_HUMAN RAGE_HUMAN] Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.<ref>PMID:19906677</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/en/2ens_consurf.spt"</scriptWhenChecked> | |||
== | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ens ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Hayashi | [[Category: Hayashi F]] | ||
[[Category: Kurosaki | [[Category: Kurosaki C]] | ||
[[Category: Wakabayashi M]] | |||
[[Category: Wakabayashi | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | [[Category: Yoshida M]] | ||
[[Category: Yoshida | |||
Latest revision as of 07:36, 9 October 2024
Solution structure of the third ig-like domain from human Advanced glycosylation end product-specific receptor
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