2eo6: Difference between revisions

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New page: left|200px {{Structure |PDB= 2eo6 |SIZE=350|CAPTION= <scene name='initialview01'>2eo6</scene> |SITE= |LIGAND= |ACTIVITY= |GENE= Blnk ([http://www.ncbi.nlm.nih.gov/T...
 
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[[Image:2eo6.jpg|left|200px]]


{{Structure
==Solution structure of the SH2 domain from mouse B-cell linker protein BLNK==
|PDB= 2eo6 |SIZE=350|CAPTION= <scene name='initialview01'>2eo6</scene>
<StructureSection load='2eo6' size='340' side='right'caption='[[2eo6]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2eo6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EO6 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= Blnk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eo6 OCA], [https://pdbe.org/2eo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eo6 RCSB], [https://www.ebi.ac.uk/pdbsum/2eo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eo6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2eo6 TOPSAN]</span></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00173 SH2]</span>
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eo6 OCA], [http://www.ebi.ac.uk/pdbsum/2eo6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2eo6 RCSB]</span>
[https://www.uniprot.org/uniprot/BLNK_MOUSE BLNK_MOUSE] Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.<ref>PMID:9705962</ref> <ref>PMID:12761551</ref> <ref>PMID:18369315</ref>
}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
'''Solution structure of the SH2 domain from mouse B-cell linker protein BLNK'''
Check<jmol>
 
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/2eo6_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
2EO6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EO6 OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eo6 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Hayashi F]]
[[Category: Hayashi, F.]]
[[Category: Kurosaki C]]
[[Category: Kurosaki, C.]]
[[Category: Sano R]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yokoyama S]]
[[Category: Sano, R.]]
[[Category: Yoshida M]]
[[Category: Yokoyama, S.]]
[[Category: Yoshida, M.]]
[[Category: b-cell adapter containing sh2 domain protein]]
[[Category: b-cell adapter containing src homology 2 domain protein]]
[[Category: cytoplasmic adapter protein]]
[[Category: lymphocyte antigen 57]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: sh2]]
[[Category: signaling protein]]
[[Category: slp-65]]
[[Category: src homology 2 domain-containing leukocyte protein of 65 kda]]
[[Category: structural genomic]]
 
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Retrieved from "https://proteopedia.org/2eo6"