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New page: left|200px {{Structure |PDB= 2epa |SIZE=350|CAPTION= <scene name='initialview01'>2epa</scene> |SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+300'>AC1</s...
 
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[[Image:2epa.jpg|left|200px]]


{{Structure
==Solution structure of the first and second zf-C2H2 domains from human Krueppel-like factor 10==
|PDB= 2epa |SIZE=350|CAPTION= <scene name='initialview01'>2epa</scene>
<StructureSection load='2epa' size='340' side='right'caption='[[2epa]]' scene=''>
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+300'>AC1</scene> and <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+400'>AC2</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
<table><tr><td colspan='2'>[[2epa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EPA FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= KLF10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2epa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2epa OCA], [https://pdbe.org/2epa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2epa RCSB], [https://www.ebi.ac.uk/pdbsum/2epa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2epa ProSAT], [https://www.topsan.org/Proteins/RSGI/2epa TOPSAN]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2epa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2epa OCA], [http://www.ebi.ac.uk/pdbsum/2epa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2epa RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/KLF10_HUMAN KLF10_HUMAN] Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'.<ref>PMID:8584037</ref>
 
== Evolutionary Conservation ==
'''Solution structure of the first and second zf-C2H2 domains from human Krueppel-like factor 10'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/2epa_consurf.spt"</scriptWhenChecked>
2EPA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPA OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2epa ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hayashi, F.]]
[[Category: Hayashi F]]
[[Category: Izumi, K.]]
[[Category: Izumi K]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Yoshida M]]
[[Category: Yoshida, M.]]
[[Category: egr-alpha]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: tgfb-inducible early growth response protein 1]]
[[Category: tieg-1]]
[[Category: transcription]]
[[Category: transforming growth factor-beta-inducible early growth response protein 1]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr  2 11:57:00 2008''
Retrieved from "https://proteopedia.org/2epa"