Cholesterol esterase: Difference between revisions

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== Function ==
== Function ==


'''Cholesterol esterase''' (ChoE) also named '''bile-acid activated lipase''' or '''sterol esterase''' catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides.<ref>PMID:11563913</ref>  
'''Cholesterol esterase''' (ChoE) also named '''bile-salt activated lipase''' or '''sterol esterase''' catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides.<ref>PMID:11563913</ref>  


== Disease ==
== Disease ==
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ChoE <scene name='52/525136/Cv/9'>ligand-binding tunnel is ca. 30 A long</scene> ({{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}). ChoE has the <scene name='52/525136/Cv/10'>polar catalytic triad Ser-His-Glu</scene> at the opening and <scene name='52/525136/Cv/11'>hydrophobic residues lining the bottom cup</scene>.<ref>PMID:12499539</ref>
ChoE <scene name='52/525136/Cv/9'>ligand-binding tunnel is ca. 30 A long</scene> ({{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}). ChoE has the <scene name='52/525136/Cv/10'>polar catalytic triad Ser-His-Glu</scene> at the opening and <scene name='52/525136/Cv/11'>hydrophobic residues lining the bottom cup</scene>.<ref>PMID:12499539</ref>
</StructureSection>
 
==3D structures of cholesterol esterase==
==3D structures of cholesterol esterase==
[[Cholesterol esterase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Cholesterol esterase
 
**[[1akn]] – bChoE – bovine<br />
**[[2bce]] – bChoE (mutant)<br />
**[[1jmy]] – hChoE - human<br />
**[[1f6w]] – hChoE catalytic domain (mutant) <br />
**[[4be9]], [[4be4]] – OpChoE – ''Ophiostoma piceae''<br />
**[[4upd]] – OpChoE (mutant) <br />
 
*Cholesterol esterase complex with bile acids


**[[1cle]] – CcChoE + cholesteryl linoleate – ''Candida cylindracea''<br />
**[[1llf]] – CcChoE + tricosanoic acid<br />
**[[1aql]] – bChoE + taurocholate
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]