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New page: left|200px {{Structure |PDB= 2hkr |SIZE=350|CAPTION= <scene name='initialview01'>2hkr</scene>, resolution 1.400Å |SITE= <scene name='pdbsite=AC1:Zhz+Binding+Site...
 
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{{Structure
==Structures of the carbinolamine and schiff-base intermediates in the reductive half-reaction of aromatic amine dehydrogenase (AADH) with p-methoxyphenylethylamine==
|PDB= 2hkr |SIZE=350|CAPTION= <scene name='initialview01'>2hkr</scene>, resolution 1.400&Aring;
<StructureSection load='2hkr' size='340' side='right'caption='[[2hkr]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Zhz+Binding+Site+For+Residue+H+1501'>AC1</scene> and <scene name='pdbsite=AC2:Zhh+Binding+Site+For+Residue+D+1502'>AC2</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=TRQ:2-AMINO-3-(6,7-DIOXO-6,7-DIHYDRO-1H-INDOL-3-YL)-PROPIONIC+ACID'>TRQ</scene>, <scene name='pdbligand=ZHH:2-(4-METHOXYPHENYL)ETHANAMINE'>ZHH</scene>, <scene name='pdbligand=ZHZ:2-(4-METHOXYPHENYL)ACETAMIDE'>ZHZ</scene>
<table><tr><td colspan='2'>[[2hkr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HKR FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aralkylamine_dehydrogenase Aralkylamine dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.99.4 1.4.99.4] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
|GENE= aauB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=511 Alcaligenes faecalis])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRQ:2-AMINO-3-(6,7-DIOXO-6,7-DIHYDRO-1H-INDOL-3-YL)-PROPIONIC+ACID'>TRQ</scene>, <scene name='pdbligand=ZHH:2-(4-METHOXYPHENYL)ETHANAMINE'>ZHH</scene>, <scene name='pdbligand=ZHZ:2-(4-METHOXYPHENYL)ACETAMIDE'>ZHZ</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02975 Me-amine-dh_L], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam06433 Me-amine-dh_H]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hkr OCA], [https://pdbe.org/2hkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hkr RCSB], [https://www.ebi.ac.uk/pdbsum/2hkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hkr ProSAT]</span></td></tr>
|RELATEDENTRY=[[2hkm|2HKM]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hkr OCA], [http://www.ebi.ac.uk/pdbsum/2hkr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hkr RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/AAUB_ALCFA AAUB_ALCFA] Oxidizes primary aromatic amines and, more slowly, some long-chain aliphatic amines, but not methylamine or ethylamine. Uses azurin as an electron acceptor to transfer electrons from the reduced tryptophylquinone cofactor.<ref>PMID:11495996</ref> <ref>PMID:16279953</ref> <ref>PMID:8188594</ref> <ref>PMID:16614214</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/2hkr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hkr ConSurf].
<div style="clear:both"></div>


'''Structures of the carbinolamine and schiff-base intermediates in the reductive half-reaction of aromatic amine dehydrogenase (AADH) with p-methoxyphenylethylamine'''
==See Also==
 
*[[Aromatic amine dehydrogenase 3D structures|Aromatic amine dehydrogenase 3D structures]]
 
== References ==
==About this Structure==
<references/>
2HKR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HKR OCA].
__TOC__
</StructureSection>
[[Category: Alcaligenes faecalis]]
[[Category: Alcaligenes faecalis]]
[[Category: Aralkylamine dehydrogenase]]
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Leys D]]
[[Category: Leys, D.]]
[[Category: Roujeinikova A]]
[[Category: Roujeinikova, A.]]
[[Category: oxidoreductase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr  2 11:57:16 2008''
Retrieved from "https://proteopedia.org/2hkr"