6nx4: Difference between revisions
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New page: '''Unreleased structure''' The entry 6nx4 is ON HOLD Authors: Piserchio, A., Will, N., Giles, D.H., Hajredini, F., Dalby, K.N., Ghose, R. Description: Structure of the C-terminal Helic... |
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==Structure of the C-terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase (eEF-2K)== | |||
<StructureSection load='6nx4' size='340' side='right'caption='[[6nx4]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6nx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NX4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nx4 OCA], [https://pdbe.org/6nx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nx4 RCSB], [https://www.ebi.ac.uk/pdbsum/6nx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nx4 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Ghose | == Function == | ||
[[Category: Giles | [https://www.uniprot.org/uniprot/EF2K_HUMAN EF2K_HUMAN] Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.<ref>PMID:14709557</ref> <ref>PMID:9144159</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Dalby KN]] | |||
[[Category: Ghose R]] | |||
[[Category: Giles DH]] | |||
[[Category: Hajredini F]] | |||
[[Category: Piserchio A]] | |||
[[Category: Will N]] | |||
Latest revision as of 07:36, 1 May 2024
Structure of the C-terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase (eEF-2K)
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