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New page: left|200px {{Structure |PDB= 3ckk |SIZE=350|CAPTION= <scene name='initialview01'>3ckk</scene>, resolution 1.55Å |SITE= <scene name='pdbsite=AC1:Sam+Binding+Site+...
 
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[[Image:3ckk.jpg|left|200px]]


{{Structure
==Crystal structure of human methyltransferase-like protein 1==
|PDB= 3ckk |SIZE=350|CAPTION= <scene name='initialview01'>3ckk</scene>, resolution 1.55&Aring;
<StructureSection load='3ckk' size='340' side='right'caption='[[3ckk]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Sam+Binding+Site+For+Residue+A+301'>AC1</scene> and <scene name='pdbsite=AC2:Gol+Binding+Site+For+Residue+A+302'>AC2</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>
<table><tr><td colspan='2'>[[3ckk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CKK FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(guanine-N(7)-)-methyltransferase tRNA (guanine-N(7)-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.33 2.1.1.33] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
|GENE= METTL1, C12orf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02390 Methyltransf_4]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ckk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckk OCA], [https://pdbe.org/3ckk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ckk RCSB], [https://www.ebi.ac.uk/pdbsum/3ckk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckk ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ckk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckk OCA], [http://www.ebi.ac.uk/pdbsum/3ckk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3ckk RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/TRMB_HUMAN TRMB_HUMAN] Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.<ref>PMID:12403464</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/3ckk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ckk ConSurf].
<div style="clear:both"></div>


'''Crystal structure of human methyltransferase-like protein 1'''
==See Also==
 
*[[TRNA methyltransferase 3D structures|TRNA methyltransferase 3D structures]]
 
== References ==
==About this Structure==
<references/>
3CKK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKK OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: tRNA (guanine-N(7)-)-methyltransferase]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H.]]
[[Category: Bochkarev A]]
[[Category: Bochkarev, A.]]
[[Category: Bountra C]]
[[Category: Bountra, C.]]
[[Category: Dobrovetsky E]]
[[Category: Dobrovetsky, E.]]
[[Category: Dong A]]
[[Category: Dong, A.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Min J]]
[[Category: Min, J.]]
[[Category: Plotnikov AN]]
[[Category: Plotnikov, A N.]]
[[Category: Weigelt J]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Wu H]]
[[Category: Weigelt, J.]]
[[Category: Zeng H]]
[[Category: Wu, H.]]
[[Category: Zeng, H.]]
[[Category: methyltransferase]]
[[Category: mettl1]]
[[Category: s-adenosyl-l-methionine]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
[[Category: trna processing]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr  2 12:00:23 2008''

Latest revision as of 12:29, 30 August 2023

Crystal structure of human methyltransferase-like protein 1

3ckk, resolution 1.55Å

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