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==Crystal structure of GIT1 PBD domain in complex with Liprin-alpha2==
==Crystal structure of GIT1 PBD domain in complex with Liprin-alpha2==
<StructureSection load='6iuh' size='340' side='right' caption='[[6iuh]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='6iuh' size='340' side='right'caption='[[6iuh]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6iuh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IUH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IUH FirstGlance]. <br>
<table><tr><td colspan='2'>[[6iuh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IUH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iuh OCA], [http://pdbe.org/6iuh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iuh RCSB], [http://www.ebi.ac.uk/pdbsum/6iuh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iuh ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iuh OCA], [https://pdbe.org/6iuh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iuh RCSB], [https://www.ebi.ac.uk/pdbsum/6iuh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iuh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GIT1_RAT GIT1_RAT]] GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. [[http://www.uniprot.org/uniprot/LIPA2_HUMAN LIPA2_HUMAN]] Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.<ref>PMID:9624153</ref> 
[https://www.uniprot.org/uniprot/GIT1_RAT GIT1_RAT] GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Liang, M]]
[[Category: Homo sapiens]]
[[Category: Wei, Z]]
[[Category: Large Structures]]
[[Category: Complex]]
[[Category: Rattus norvegicus]]
[[Category: Protein binding]]
[[Category: Liang M]]
[[Category: Wei Z]]
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