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==Structure of the Ysh1-Mpe1 nuclease complex from S.cerevisiae==
==Structure of the Ysh1-Mpe1 nuclease complex from S.cerevisiae==
<StructureSection load='6i1d' size='340' side='right' caption='[[6i1d]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
<StructureSection load='6i1d' size='340' side='right'caption='[[6i1d]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6i1d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I1D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I1D FirstGlance]. <br>
<table><tr><td colspan='2'>[[6i1d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I1D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YSH1, BRR5, YLR277C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), MPE1, YKL059C, YKL316 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i1d OCA], [http://pdbe.org/6i1d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i1d RCSB], [http://www.ebi.ac.uk/pdbsum/6i1d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i1d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i1d OCA], [https://pdbe.org/6i1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i1d RCSB], [https://www.ebi.ac.uk/pdbsum/6i1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i1d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/YSH1_YEAST YSH1_YEAST]] Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Has endonuclease activity.<ref>PMID:15037765</ref> [[http://www.uniprot.org/uniprot/MPE1_YEAST MPE1_YEAST]] Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.
[https://www.uniprot.org/uniprot/YSH1_YEAST YSH1_YEAST] Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Has endonuclease activity.<ref>PMID:15037765</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Large Structures]]
[[Category: Boreikaite, V]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Casanal, A]]
[[Category: Boreikaite V]]
[[Category: Degliesposti, G]]
[[Category: Casanal A]]
[[Category: Girbig, M]]
[[Category: Degliesposti G]]
[[Category: Hill, C H]]
[[Category: Girbig M]]
[[Category: Kubik, P]]
[[Category: Hill CH]]
[[Category: Kumar, A]]
[[Category: Kubik P]]
[[Category: Loeffelholz, O von]]
[[Category: Kumar A]]
[[Category: Mariani, A]]
[[Category: Mariani A]]
[[Category: Maslen, S]]
[[Category: Maslen S]]
[[Category: Passmore, L A]]
[[Category: Passmore LA]]
[[Category: Skehel, M]]
[[Category: Skehel M]]
[[Category: 3' end]]
[[Category: Von Loeffelholz O]]
[[Category: Cleavage]]
[[Category: Cpf]]
[[Category: Endonuclease]]
[[Category: Gene regulation]]
[[Category: Metallo-beta-lactamase]]
[[Category: Mrna]]
[[Category: Nuclease]]
[[Category: Polya]]
[[Category: Polyadenylation]]
[[Category: Pre-mrna]]
Retrieved from "https://proteopedia.org/6i1d"