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==crystal structure of human katanin AAA ATPase domain==
==crystal structure of human katanin AAA ATPase domain==
<StructureSection load='5zql' size='340' side='right' caption='[[5zql]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
<StructureSection load='5zql' size='340' side='right'caption='[[5zql]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5zql]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZQL FirstGlance]. <br>
<table><tr><td colspan='2'>[[5zql]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZQL FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Microtubule-severing_ATPase Microtubule-severing ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.3 3.6.4.3] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.007&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zql OCA], [http://pdbe.org/5zql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zql RCSB], [http://www.ebi.ac.uk/pdbsum/5zql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zql ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zql OCA], [https://pdbe.org/5zql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zql RCSB], [https://www.ebi.ac.uk/pdbsum/5zql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zql ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KTNA1_HUMAN KTNA1_HUMAN]] Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.[HAMAP-Rule:MF_03023]<ref>PMID:10751153</ref> <ref>PMID:11870226</ref> <ref>PMID:19287380</ref>
[https://www.uniprot.org/uniprot/KTNA1_HUMAN KTNA1_HUMAN] Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.[HAMAP-Rule:MF_03023]<ref>PMID:10751153</ref> <ref>PMID:11870226</ref> <ref>PMID:19287380</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Microtubule-severing ATPase]]
[[Category: Homo sapiens]]
[[Category: Kim, E E]]
[[Category: Large Structures]]
[[Category: Shin, S C]]
[[Category: Kim EE]]
[[Category: Aaa atpase]]
[[Category: Shin SC]]
[[Category: Hydrolase]]
[[Category: Katanin p60]]
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