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==The structure of the TRAF domain of human TRAF4==
==The structure of the TRAF domain of human TRAF4==
<StructureSection load='3zjb' size='340' side='right' caption='[[3zjb]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
<StructureSection load='3zjb' size='340' side='right'caption='[[3zjb]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3zjb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZJB FirstGlance]. <br>
<table><tr><td colspan='2'>[[3zjb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZJB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjb OCA], [http://pdbe.org/3zjb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zjb RCSB], [http://www.ebi.ac.uk/pdbsum/3zjb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zjb ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjb OCA], [https://pdbe.org/3zjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zjb RCSB], [https://www.ebi.ac.uk/pdbsum/3zjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zjb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>
[https://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[TNF receptor-associated factor|TNF receptor-associated factor]]
*[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Alpy, F]]
[[Category: Large Structures]]
[[Category: McEwen, A G]]
[[Category: Alpy F]]
[[Category: Nomine, Y]]
[[Category: McEwen AG]]
[[Category: Poussin-Courmontagne, P]]
[[Category: Nomine Y]]
[[Category: Rio, M C]]
[[Category: Poussin-Courmontagne P]]
[[Category: Rogna, D]]
[[Category: Rio M-C]]
[[Category: Rousseau, A]]
[[Category: Rogna D]]
[[Category: Tomasetto, C]]
[[Category: Rousseau A]]
[[Category: Signaling protein]]
[[Category: Tomasetto C]]
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