Adenylyl cyclase 3D structures: Difference between revisions

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New page: == 3D Structures of Adenylyl cyclase == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *ADCY **2ev1, 2ev2...
 
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== 3D Structures of Adenylyl cyclase ==
== 3D Structures of [[Adenylyl cyclase]] ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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*ADCY
*ADCY


**[[2ev1]], [[2ev2]], [[2ev3]], [[2ev4]] – MtADCY N-terminal – ''Mycobacterium tuberculosis''<br />
**[[8sl4]] – hADCY 5 - human - Cryo EM<br />
**[[1y10]], [[1y11]], [[4p2m]], [[4p2x]] – MtADCY holoenzyme<br />
**[[8sl3]] – hADCY 5 + G protein + geranyl - Cryo EM<br />
**[[8buz]], [[8bv5]] – bADCY 8 + G protein + forskolin + GSP – bovine - Cryo EM<br />
**[[7pd4]] – bADCY 9 - bovine - Cryo EM<br />
**[[1ab8]] – ADCY C2 domain - rat<br />
**[[8h92]] – ADCY - jujube<br />
**[[7yz9]], [[7yzi]], [[7yzk]] – MtADCY + nanobody + GDP derivative - ''Mycobacterium tuberculosis'' - Cryo EM<br />
**[[4p2m]], [[4p2x]] – MtADCY residues 212-443
**[[1y10]], [[1y11]] – MtADCY residues 1-397
**[[4p2f]] – MtADCY (mutant)<br />
**[[4p2f]] – MtADCY (mutant)<br />
**[[4wp3]] – MaADCY – ''Mycobacterium avium''<br />
**[[4wp3]] – MaADCY – ''Mycobacterium avium''<br />
**[[2fjt]] – ADCY 4 – ''Yersinia pestis''<br />
**[[2fjt]] – ADCY 4 – ''Yersinia pestis''<br />
**[[1ykd]] – ADCY – ''Anabaena''<br />
**[[1ykd]] – ADCY – ''Anabaena''<br />
**[[1ab8]] – ADCY C2 domain - rat


*Photoactivated adenylyl cyclase
*Photoactivated adenylyl cyclase


**[[5m27]], [[5m2a]], [[5mbb]], [[5mbc]], [[5mbd]], [[5mbe]] – BeADCY subunit b + FMN – ''Beggiatoa''<br />
**[[5m27]], [[5m2a]], [[5mbb]], [[5mbc]], [[5mbd]], [[5mbe]] – BePAC subunit b + FMN – ''Beggiatoa''<br />
**[[5mbg]], [[5mbh]], [[5mbj]], [[5mbk]], [[5nby]]  – BeADCY subunit b (mutant) + FMN <br />
**[[5mbg]], [[5mbh]], [[5mbj]], [[5mbk]], [[5nby]]  – BePAC subunit b (mutant) + FMN <br />
**[[5x4t]], [[5x4u]], [[5x4v]]  – ADCY + FMN – ''Oscillatoria acuminata''<br />
**[[5x4t]], [[5x4u]], [[5x4v]]  – PAC + FMN – ''Oscillatoria acuminata''<br />


* ADCY catalytic domain  
* ADCY catalytic domain residues 1-469


**[[1yk9]], [[1ybt]], [[1ybu]] – MtADCY catalytic domain<br />
**[[4clf]], [[4cly]], [[4cm2]], [[4oyw]], [[8il7]] – hADCY 10 – human<br />
**[[3r5g]] - ADCY catalytic domain – ''Pseudomonas aeruginosa''<br />
**[[4clk]], [[4clw]], [[4cm0]], [[4usw]] – hADCY 10 + ATP derivative<br />
**[[1fx2]], [[1fx4]] - ADCY catalytic domain – ''Trypanosoma brucei''<br />
**[[4clp]], [[4oyx]], [[4usu]] – hADCY 10 + AMP derivative<br />
**[[2bw7]] - SpADCY catalytic domain+catechol estrogen – ''Spirulina platensis''<br />
**[[4cll]], [[4clz]], [[4oya]], [[4oyb]], [[4oyi]], [[4oym]], [[4oyo]], [[4oyp]], [[4oyz]], [[4oz2]], [[4oz3]] – hADCY 10  + bicarbonate<br />
**[[1wc0]] – SpADCY catalytic domain+methylene ATP<br />
**[[4cls]], [[4clu]], [[4ust]], [[4usv]] – hADCY 10 + pyrophosphate<br />
**[[1wc1]], [[1wc3]], [[1wc4]], [[1wc5]], [[1wc6]] - SpADCY catalytic domain+ATP derivatives<br />
**[[4clt]] – hADCY 10 + pyrophosphate + AMP derivative<br />
**[[5d0r]], [[5iv4]], [[7ovd]], [[8b75]], [[8cnh]], [[8co7]], [[8coj]], [[8cot]] – hADCY 10 + inhibitor<br />
**[[5iv3]] – hADCY 10 + inhibitor + ATP derivative<br />
**[[6r3q]], [[6r4o]], [[6r4p]] – bADCY 9 + guanine nucleotide-binding protein - Cryo EM<br />
**[[3maa]] – dADCY 5 (mutant)+ADCY 2 C2a+guanine nucleotide binding protein G – dog<br />
**[[3maa]] – dADCY 5 (mutant)+ADCY 2 C2a+guanine nucleotide binding protein G – dog<br />
**[[3g82]] - dADCY 5 (mutant)+ADCY 2 C1a+guanine nucleotide binding protein G<br />
**[[3g82]] - dADCY 5 (mutant)+ADCY 2 C1a+guanine nucleotide binding protein G<br />
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**[[1cjv]] - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GDP+Mg+Zn+ATP<br />
**[[1cjv]] - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GDP+Mg+Zn+ATP<br />
**[[1azs]] - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GDP+Mg<br />
**[[1azs]] - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GDP+Mg<br />
**[[4clf]], [[4cly]], [[4cm2]], [[4oyw]] – hADCY 10 – human<br />
**[[3r5g]] - ADCY – ''Pseudomonas aeruginosa''<br />
**[[4clk]], [[4clw]], [[4cm0]], [[4usw]] – hADCY 10 + ATP derivative<br />
**[[1yk9]], [[1ybt]], [[1ybu]] – MtADCY <br />
**[[4clp]], [[4oyx]], [[4usu]] – hADCY 10 + AMP derivative<br />
 
**[[4cll]], [[4clz]], [[4oya]], [[4oyb]], [[4oyi]], [[4oym]], [[4oyo]], [[4oyp]], [[4oyz]], [[4oz2]], [[4oz3]] – hADCY 10  + bicarbonate<br />
*ADCY complex
**[[4cls]], [[4clu]], [[4ust]], [[4usv]] – hADCY 10 + pyrophosphate<br />
 
**[[4clt]] – hADCY 10 + pyrophosphate + AMP derivative<br />
**[[6r3q]], [[6r4o]], [[6r4p]], [[7pdf]] – bADCY 9 + guanine nucleotide-binding protein - Cryo EM<br />
**[[5d0r]], [[5iv4]] – hADCY 10 + inhibitor<br />
**[[7pde]] – bADCY 9 + guanine nucleotide-binding protein + GDP derivative - Cryo EM<br />
**[[5iv3]] – hADCY 10 + inhibitor + ATP derivative<br />
**[[7pd8]], [[7pdd]], [[7pdg]], [[7pdh]] – bADCY 9 + DARPin C4 - Cryo EM<br />
**[[4wp8]], [[4wp9]] – MaADCY + ATP derivative<br />
**[[4wp8]], [[4wp9]] – MaADCY + ATP derivative<br />
**[[4wpa]] – MaADCY + pyrophosphate <br />
**[[4wpa]] – MaADCY residues 53-216 + pyrophosphate <br />
**[[1fx2]], [[1fx4]] - ADCY 888-1123 – ''Trypanosoma brucei''<br />
**[[2bw7]] - SpADCY catalytic domain+catechol estrogen – ''Spirulina platensis''<br />
**[[1wc0]] – SpADCY catalytic domain+methylene ATP<br />
**[[1wc1]], [[1wc3]], [[1wc4]], [[1wc5]], [[1wc6]] - SpADCY catalytic domain+ATP derivatives<br />


*Adenylate/nucleotidyl cyclase toxin (For anthrax edema factor see [[Anthrax edema factor 3D structures]])


* Anthrax toxA family of adenylate/nucleotidyl cyclases (edema factors)
**[[1k8t]], [[1lvc]], [[1pk0]], [[1s26]], [[1sk6]], [[1xfv]], [[1xfu]], [[1k90]], [[1xfw]], [[1xfx]], [[1xfz]], [[1xfy]], [[1k93]], [[1y0v]] - Bifunctional hemolysin/adenylate cyclase toxin (C-terminal) + calmodulin + ligands - ''Bacillus anthracis''<br />
**[[2col]], [[1zot]], [[1yru]], [[1yrt]] - CyaA adenylate cyclase toxin – ''Bordetella pertussis''<br />
**[[2col]], [[1zot]], [[1yru]], [[1yrt]] - CyaA adenylate cyclase toxin – ''Bordetella pertussis''<br />
**[[5xnw]] – ExoY nucleotidyl cyclase toxin – ''Pseudomonas aeruginosa''<br />
**[[5xnw]] – ExoY nucleotidyl cyclase toxin – ''Pseudomonas aeruginosa''<br />
**[[6uzb]], [[6uzd]], [[6uze]] – BaADCY + antigen – Cryo EM<br />


*ADCY-associated protein
*ADCY-associated protein


**[[1k8f]] - hCAP C-terminal <br />
**[[6fm2]] - mCAP residues 317-474 + actin + ADP – mouse<br />
**[[6fm2]] - mCAP residues 317-474 + actin + ADP – mouse<br />
**[[6rsq]] - mCAP HFD domain residues 41-216<br />
**[[6rsw]] - mCAP HFD domain (mutnt) + actin + twinfilin<br />
**[[1k4z]] - yCAP C-terminal – yeast<br />
**[[1k4z]] - yCAP C-terminal – yeast<br />
**[[1kq5]] - yCAP C-terminal (mutant)<br />
**[[1kq5]] - yCAP C-terminal (mutant)<br />
**[[1k8f]] - hCAP C-terminal <br />
**[[1s0p]], [[1tjf]] - CAP N-terminal – ''Dictyostelium discoideum''<br />
**[[1s0p]], [[1tjf]] - CAP N-terminal – ''Dictyostelium discoideum''<br />
**[[6fm2]] - CAP residues 317-474 + actin + ADP – mouse<br />




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