6jc4: Difference between revisions
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==Crystal structure of the urease accessory protein UreF from Klebsiella pneumoniae== | |||
<StructureSection load='6jc4' size='340' side='right'caption='[[6jc4]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6jc4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JC4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jc4 OCA], [https://pdbe.org/6jc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jc4 RCSB], [https://www.ebi.ac.uk/pdbsum/6jc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jc4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/UREF_KLEP7 UREF_KLEP7] Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.[HAMAP-Rule:MF_01385] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Klebsiella pneumoniae is an opportunistic pathogen that mostly affects those with weakened immune systems. Urease is a vital enzyme that can hydrolyze urea to ammonia and carbon dioxide as a source of nitrogen for growth. Urease is also a K. pneumoniae virulence factor that enables survival of the bacterium under nutrient-limiting conditions. UreF, an important nickel-binding urease accessory protein, is involved in the insertion of Ni(2+) into the active site of urease. Here, the crystal structure of UreF from K. pneumoniae (KpUreF) is reported. Functional data show that KpUreF forms a stable dimer in solution. These results may provide a starting point for the design of urease inhibitors. | |||
Structural characterization of the urease accessory protein UreF from Klebsiella pneumoniae.,Liu S, Wu W, Zhao Q, Liang H, Che S, Zhang H, Liu R, Zhang Q, Bartlam M Acta Crystallogr F Struct Biol Commun. 2022 Feb 1;78(Pt 2):75-80. doi:, 10.1107/S2053230X22000474. Epub 2022 Jan 31. PMID:35102896<ref>PMID:35102896</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6jc4" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Urease accessory protein 3D structures|Urease accessory protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Klebsiella pneumoniae]] | |||
[[Category: Large Structures]] | |||
[[Category: Bartlam M]] | |||
[[Category: Wu W]] | |||
[[Category: Zhang Q]] | |||
Latest revision as of 19:27, 29 May 2024
Crystal structure of the urease accessory protein UreF from Klebsiella pneumoniae
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