4b04: Difference between revisions
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<StructureSection load='4b04' size='340' side='right'caption='[[4b04]], [[Resolution|resolution]] 2.21Å' scene=''> | <StructureSection load='4b04' size='340' side='right'caption='[[4b04]], [[Resolution|resolution]] 2.21Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4b04]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4b04]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B04 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.205Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b04 OCA], [https://pdbe.org/4b04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b04 RCSB], [https://www.ebi.ac.uk/pdbsum/4b04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b04 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DUS26_HUMAN DUS26_HUMAN] Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).<ref>PMID:15796912</ref> <ref>PMID:16924234</ref> <ref>PMID:17001450</ref> <ref>PMID:16581800</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[TATA- | *[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]] | ||
*[[MAP kinase phosphatase|MAP kinase phosphatase]] | |||
*[[TATA-binding protein 3D structures|TATA-binding protein 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Chi | [[Category: Large Structures]] | ||
[[Category: Kim | [[Category: Chi S-W]] | ||
[[Category: Lee | [[Category: Kim SJ]] | ||
[[Category: Park | [[Category: Lee DY]] | ||
[[Category: Won | [[Category: Park SG]] | ||
[[Category: Yokoyama | [[Category: Won E-Y]] | ||
[[Category: Yokoyama S]] | |||
