6jma: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "6jma" [edit=sysop:move=sysop] |
No edit summary |
||
| (6 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==cryo-EM structure of DOT1L bound to H2B ubiquitinated nucleosome== | |||
<SX load='6jma' size='340' side='right' viewer='molstar' caption='[[6jma]], [[Resolution|resolution]] 6.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6jma]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JMA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JMA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jma OCA], [https://pdbe.org/6jma PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jma RCSB], [https://www.ebi.ac.uk/pdbsum/6jma PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jma ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | |||
==See Also== | |||
*[[Histone 3D structures|Histone 3D structures]] | |||
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |||
[[Category: | __TOC__ | ||
[[Category: Jang | </SX> | ||
[[Category: Song | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Xenopus laevis]] | |||
[[Category: Jang S]] | |||
[[Category: Song JJ]] | |||
Latest revision as of 10:38, 27 March 2024
cryo-EM structure of DOT1L bound to H2B ubiquitinated nucleosome
| ||||||||
