6qng: Difference between revisions
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==Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide== | |||
<StructureSection load='6qng' size='340' side='right'caption='[[6qng]], [[Resolution|resolution]] 1.67Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6qng]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QNG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=J95:~{N}-butyl-4-chloranyl-2-(cyclohexylamino)-5-sulfamoyl-benzamide'>J95</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qng OCA], [https://pdbe.org/6qng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qng RCSB], [https://www.ebi.ac.uk/pdbsum/6qng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qng ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN] Defects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:[https://omim.org/entry/143860 143860]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.<ref>PMID:21035102</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN] Reversible hydration of carbon dioxide. | |||
==See Also== | |||
*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Dvinskis | __TOC__ | ||
[[Category: Leitans | </StructureSection> | ||
[[Category: Tars | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Dvinskis E]] | |||
[[Category: Leitans J]] | |||
[[Category: Tars K]] | |||
Latest revision as of 12:04, 24 January 2024
Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide
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