ERGIC-53: Difference between revisions
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Some ER storage diseases have relationship with ERGIC-53. ERGIC-53 is required for the propagation of arenavirus, coronavirus and filovirus<ref>PMID:24237698</ref>. | Some ER storage diseases have relationship with ERGIC-53. ERGIC-53 is required for the propagation of arenavirus, coronavirus and filovirus<ref>PMID:24237698</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
ERGIC-53 contains an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain (CRD), a stalk region, a transmembrane domain and a short cytoplasmic domain. The <scene name='74/748868/Cv/3'>mannose-binding pocket of ERGIC-53 contains a Ca+2 ion as well</scene><ref>PMID:23709226</ref>. | ERGIC-53 contains an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain (CRD), a stalk region, a transmembrane domain and a short cytoplasmic domain. The <scene name='74/748868/Cv/3'>mannose-binding pocket of ERGIC-53 contains a Ca+2 ion as well</scene><ref>PMID:23709226</ref>. Water molecules are shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of ERGIC-53== | ==3D structures of ERGIC-53== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[4ygb]], [[4ygc]], [[4ygd]], [[4yge]], [[3wht]], [[3lcp]], [[3a4u]] – hERGIC-53 CRD domain + MCFD2 + Ca | ERGIC-53; Domains – CRD 31-269 | ||
[[8jp4]], [[8jp5]], [[8jp6]], [[8jp7]], [[8jp8]], [[8jp9]], [[8jpg]] – hERGIC-53 + MCFD2 + Ca - human - Cryo EM<br /> | |||
[[4ygb]], [[4ygc]], [[4ygd]], [[4yge]], [[3wht]], [[3lcp]], [[3a4u]] – hERGIC-53 CRD domain + MCFD2 + Ca<br /> | |||
[[3whu]], [[3wnx]] – hERGIC-53 CRD domain + MCFD2 + Ca + mannose<br /> | [[3whu]], [[3wnx]] – hERGIC-53 CRD domain + MCFD2 + Ca + mannose<br /> | ||
[[4gkx]] – hERGIC-53 CRD domain + Ca <br /> | [[4gkx]] – hERGIC-53 CRD domain + Ca <br /> | ||
