4bsi: Difference between revisions

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<StructureSection load='4bsi' size='340' side='right'caption='[[4bsi]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
<StructureSection load='4bsi' size='340' side='right'caption='[[4bsi]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4bsi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/turkey/it/214845/02(h7n3)) Influenza a virus (a/turkey/it/214845/02(h7n3))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BSI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BSI FirstGlance]. <br>
<table><tr><td colspan='2'>[[4bsi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/turkey/Italy/214845/2002(H7N3)) Influenza A virus (A/turkey/Italy/214845/2002(H7N3))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BSI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bsa|4bsa]], [[4bsb|4bsb]], [[4bsc|4bsc]], [[4bsd|4bsd]], [[4bse|4bse]], [[4bsf|4bsf]], [[4bsg|4bsg]], [[4bsh|4bsh]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900067:3-sialyl-N-acetyllactosamine'>PRD_900067</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bsi OCA], [http://pdbe.org/4bsi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bsi RCSB], [http://www.ebi.ac.uk/pdbsum/4bsi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bsi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bsi OCA], [https://pdbe.org/4bsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bsi RCSB], [https://www.ebi.ac.uk/pdbsum/4bsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bsi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/G0KQM4_9INFA G0KQM4_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]  
[https://www.uniprot.org/uniprot/G0KQM4_9INFA G0KQM4_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Hemagglutinin|Hemagglutinin]]
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bennett, M S]]
[[Category: Bennett MS]]
[[Category: Collins, P J]]
[[Category: Collins PJ]]
[[Category: Daniels, R S]]
[[Category: Daniels RS]]
[[Category: Gamblin, S J]]
[[Category: Gamblin SJ]]
[[Category: Haire, L F]]
[[Category: Haire LF]]
[[Category: Martin, S R]]
[[Category: Martin SR]]
[[Category: McCauley, J W]]
[[Category: McCauley JW]]
[[Category: Skehel, J J]]
[[Category: Skehel JJ]]
[[Category: Walker, P A]]
[[Category: Walker PA]]
[[Category: Wharton, S A]]
[[Category: Wharton SA]]
[[Category: Xiong, X]]
[[Category: Xiong X]]
[[Category: Bird flu]]
[[Category: Fowl plague virus]]
[[Category: Glycoprotein]]
[[Category: Glycosylation]]
[[Category: H5n1]]
[[Category: H7n3]]
[[Category: H7n9]]
[[Category: Influenza]]
[[Category: Sialic acid]]
[[Category: Sialyllactosamine]]
[[Category: Viral protein]]
[[Category: Virus receptor]]
Retrieved from "https://proteopedia.org/4bsi"