Outer surface protein: Difference between revisions
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<StructureSection load='2af5' size='350' side='right' caption='Outer surface protein A (PDB entry [[2af5]])' scene=''> | <StructureSection load='2af5' size='350' side='right' caption='Outer surface protein A (PDB entry [[2af5]])' scene=''> | ||
'''Outer surface proteins''' (Osp) are produced by the bacteria Borrelia burgdorferi which causes Lyme disease. OspA and OspB are upregulated when the bacteria enter the tick. '''OspA'''<ref>PMID:10953031</ref> contributes to the colonization of the gut by the bacteria. | '''Outer surface proteins''' (Osp) are produced by the bacteria Borrelia burgdorferi which causes Lyme disease. OspA and OspB are upregulated when the bacteria enter the tick. | ||
*'''OspA'''<ref>PMID:10953031</ref> contributes to the colonization of the gut by the bacteria. | |||
* '''OspB'''<ref>PMID:17352535</ref>, '''OspC'''<ref>PMID:26438793</ref> and '''OspE'''<ref>PMID:8262642</ref> are major antigens on the surface of the Lyme disease spirochetes when it is being transmitted to humans. For more details see:<br /> | |||
OspA - <br /> | OspA - <br /> | ||
*[[G09SecL04Tpc2]]<br /> | *[[G09SecL04Tpc2]]<br /> | ||
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* OspA | * OspA | ||
** [[ | |||
** [[2af5]], [[2fkg]], [[2fkj]], [[2hkd]], [[2oyb]], [[6j6b]], [[6j6c]], [[6j6d]], [[6j6e]], [[8xwg]], [[9jsa]] – BbOspA – ''Borrelia burgdorferi''<br /> | |||
** [[2g8c]], [[2i5z]], [[2ol6]], [[2ol7]], [[2ol8]], [[2oy1]], [[2i5v]], [[2oy5]], [[2oy7]], [[2oy8]], [[2pi3]], [[3aum]], [[3cka]], | ** [[2g8c]], [[2i5z]], [[2ol6]], [[2ol7]], [[2ol8]], [[2oy1]], [[2i5v]], [[2oy5]], [[2oy7]], [[2oy8]], [[2pi3]], [[3aum]], [[3cka]], | ||
** [[3ckf]], [[3ckg]], [[3ec5]], [[3eex]], [[6j49]], [[6j48]], [[5b2a]], [[6j47]] - OspA (mutant) <br /> | ** [[3ckf]], [[3ckg]], [[3ec5]], [[3eex]], [[6j49]], [[6j48]], [[5b2a]], [[6j47]], [[5ys7]], [[5z1o]], [[6ais]], [[6ics]], [[6idc]], [[6iei]], [[6iys]], [[6j47]], [[6j48]], [[6j49]], [[6j5m]], [[6j5n]], [[6j5o]], [[6j5p]], [[6j5q]], [[6j5r]], [[6kt1]], [[6ljy]], [[6kk9]], [[6kwj]], [[6kwu]], [[6kwv]], [[7fdd]], [[7fjr]] - OspA (mutant) <br /> | ||
**[[5izt]] – OspA C-terminal<br /> | **[[5izt]] – OspA C-terminal<br /> | ||
**[[7jwg]], [[7t25]], [[8tuz]], [[8tv3]], [[8tvd]], [[9byf]], [[9cds]] – OspA + antibody<br /> | |||
**[[1osp]], [[1fj1]] – OspA (mutant) + antibody<br /> | |||
* OspB | * OspB | ||
** [[ | |||
** [[ | **[[2yn7]] – OspB<br /> | ||
** [[ | **[[1p4p]] – OspB C terminal<br /> | ||
**[[1rjl]] - OspB+ antibody<br /> | |||
* OspC | * OspC | ||
** [[1ggq]], [[1g5z]] – OspC<br /> | |||
** [[1f1m]] – OspC (mutant) | **[[1ggq]], [[1g5z]], [[7bml]] – OspC<br /> | ||
**[[1f1m]] – OspC (mutant)<br /> | |||
**[[9bif]], [[9c1s]] – OspC type A + antibody<br /> | |||
**[[7uj2]] – OspC type B<br /> | |||
**[[9c24]] – OspC type B + antibody<br /> | |||
**[[7uj2]] – OspC type B<br /> | |||
**[[7uj6]] – OspC type K<br /> | |||
**[[7uij]] – OspC + antibody<br /> | |||
**[[7nen]] – OspC – ''Borrelia garinii''<br /> | |||
* OspE | * OspE | ||
** [[2m4f]] – OspE – NMR<br /> | |||
** [[4j38]] – OspE + complement factor H<br /> | **[[2m4f]] – OspE – NMR<br /> | ||
**[[4j38]] – OspE + complement factor H<br /> | |||
**[[5nbq]] – OspE + complement factor H + complement C3<br /> | **[[5nbq]] – OspE + complement factor H + complement C3<br /> | ||
*Paralogous family 12 Osp | |||
**[[8s2f]], [[8s2p]] – BBH37 <br /> | |||
**[[8cqn]], [[8cqo]] – BBK01 <br /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
