4d2g: Difference between revisions

<table><tr><td colspan='2'>[[4d2g]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D2G FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d2g OCA], [https://pdbe.org/4d2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d2g RCSB], [https://www.ebi.ac.uk/pdbsum/4d2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d2g ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN] Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.<ref>PMID:19443450</ref> <ref>PMID:18719106</ref>  

[[Category: Homo sapiens]]

[[Category: Bernardo P]]

[[Category: Blanco FJ]]

[[Category: Castillo F]]

[[Category: Cordeiro TN]]

[[Category: DeBiasio A]]

[[Category: Diercks T]]

[[Category: Ibanez A]]

[[Category: Lelli M]]

[[Category: Luque I]]

[[Category: Merino N]]

[[Category: Molina R]]

[[Category: Montoya G]]

[[Category: Mortuza G]]

[[Category: Villate M]]