4c9r: Difference between revisions

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<StructureSection load='4c9r' size='340' side='right'caption='[[4c9r]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4c9r' size='340' side='right'caption='[[4c9r]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4c9r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Silurana_(xenopus)_tropicalis Silurana (xenopus) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C9R FirstGlance]. <br>
<table><tr><td colspan='2'>[[4c9r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C9R FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c84|4c84]], [[4c85|4c85]], [[4c86|4c86]], [[4c8a|4c8a]], [[4c8c|4c8c]], [[4c8f|4c8f]], [[4c8p|4c8p]], [[4c8t|4c8t]], [[4c8u|4c8u]], [[4c8v|4c8v]], [[4c8w|4c8w]], [[4c99|4c99]], [[4c9a|4c9a]], [[4c9e|4c9e]], [[4c9u|4c9u]], [[4c9v|4c9v]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c9r OCA], [http://pdbe.org/4c9r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c9r RCSB], [http://www.ebi.ac.uk/pdbsum/4c9r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c9r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c9r OCA], [https://pdbe.org/4c9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c9r RCSB], [https://www.ebi.ac.uk/pdbsum/4c9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c9r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ZNRF3_XENTR ZNRF3_XENTR]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity). [[http://www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR]] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).  
[https://www.uniprot.org/uniprot/ZNRF3_XENTR ZNRF3_XENTR] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Jones, E Y]]
[[Category: Xenopus tropicalis]]
[[Category: Zebisch, M]]
[[Category: Jones EY]]
[[Category: Lgr4]]
[[Category: Zebisch M]]
[[Category: Lgr5]]
[[Category: Lgr6]]
[[Category: Ligase-signaling protein complex]]
[[Category: Membrane]]
[[Category: R-spo]]
[[Category: R-spondin]]
[[Category: Receptor]]
[[Category: Rnf43]]
[[Category: Rspo]]
[[Category: Rspo1]]
[[Category: Rspo3]]
[[Category: Rspo4]]
[[Category: Signalling]]
[[Category: Wnt]]
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