6o0r: Difference between revisions

Latest revision as of 14:49, 13 March 2024

Crystal structure of the TIR domain from human SARM1 in complex with glycerol

Structural highlights

6o0r is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Ligands:	GOL
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SARM1_HUMAN Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.^[1] ^[2] ^[3] ^[4]

References

↑ Liberati NT, Fitzgerald KA, Kim DH, Feinbaum R, Golenbock DT, Ausubel FM. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6593-8. PMID:15123841 doi:https://dx.doi.org/10.1073/pnas.0308625101
↑ Carty M, Goodbody R, Schroder M, Stack J, Moynagh PN, Bowie AG. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol. 2006 Oct;7(10):1074-81. doi: 10.1038/ni1382. Epub 2006 Sep 10. PMID:16964262 doi:https://dx.doi.org/10.1038/ni1382
↑ O'Neill LA. DisSARMing Toll-like receptor signaling. Nat Immunol. 2006 Oct;7(10):1023-5. doi: 10.1038/ni1006-1023. PMID:16985498 doi:https://dx.doi.org/10.1038/ni1006-1023
↑ Peng J, Yuan Q, Lin B, Panneerselvam P, Wang X, Luan XL, Lim SK, Leung BP, Ho B, Ding JL. SARM inhibits both TRIF- and MyD88-mediated AP-1 activation. Eur J Immunol. 2010 Jun;40(6):1738-47. doi: 10.1002/eji.200940034. PMID:20306472 doi:https://dx.doi.org/10.1002/eji.200940034

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Liberati NT, Fitzgerald KA, Kim DH, Feinbaum R, Golenbock DT, Ausubel FM. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6593-8. PMID:15123841 doi:https://dx.doi.org/10.1073/pnas.0308625101

[2] Carty M, Goodbody R, Schroder M, Stack J, Moynagh PN, Bowie AG. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol. 2006 Oct;7(10):1074-81. doi: 10.1038/ni1382. Epub 2006 Sep 10. PMID:16964262 doi:https://dx.doi.org/10.1038/ni1382

[3] O'Neill LA. DisSARMing Toll-like receptor signaling. Nat Immunol. 2006 Oct;7(10):1023-5. doi: 10.1038/ni1006-1023. PMID:16985498 doi:https://dx.doi.org/10.1038/ni1006-1023

[4] Peng J, Yuan Q, Lin B, Panneerselvam P, Wang X, Luan XL, Lim SK, Leung BP, Ho B, Ding JL. SARM inhibits both TRIF- and MyD88-mediated AP-1 activation. Eur J Immunol. 2010 Jun;40(6):1738-47. doi: 10.1002/eji.200940034. PMID:20306472 doi:https://dx.doi.org/10.1002/eji.200940034

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6o0r is ON HOLD  until Paper Publication
+==Crystal structure of the TIR domain from human SARM1 in complex with glycerol==
+<StructureSection load='6o0r' size='340' side='right'caption='[[6o0r]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors: Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Deerain, N., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6o0r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O0R FirstGlance]. <br>
-Description: Crystal structure of the TIR domain from human SARM1 in complex with glycerol
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Kobe, B]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o0r OCA], [https://pdbe.org/6o0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o0r RCSB], [https://www.ebi.ac.uk/pdbsum/6o0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o0r ProSAT]</span></td></tr>
-[[Category: Ve, T]]
+</table>
-[[Category: Ericsson, D.J]]
+== Function ==
-[[Category: Chen, J]]
+[https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref>
-[[Category: Casey, L]]
+== References ==
-[[Category: Manik, M.K]]
+<references/>
-[[Category: Nanson, J.D]]
+__TOC__
-[[Category: Foley, G]]
+</StructureSection>
-[[Category: Zhang, X]]
+[[Category: Homo sapiens]]
-[[Category: Tiancong, Q]]
+[[Category: Large Structures]]
-[[Category: Lai, J]]
+[[Category: Boden M]]
-[[Category: Williams, S.J]]
+[[Category: Bosanac T]]
-[[Category: Dry, I.B]]
+[[Category: Burdett H]]
-[[Category: Burdett, H]]
+[[Category: Casey L]]
-[[Category: Rathjen, J.P]]
+[[Category: Chen J]]
-[[Category: Horsefield, S]]
+[[Category: Coleman MP]]
-[[Category: Dodds, P.N]]
+[[Category: Deerain N]]
-[[Category: Boden, M]]
+[[Category: Dodds PN]]
-[[Category: Von Itzstein, M]]
+[[Category: Dry IB]]
-[[Category: Deerain, N]]
+[[Category: Ericsson DJ]]
-[[Category: Hughes, R.O]]
+[[Category: Foley G]]
-[[Category: Coleman, M.P]]
+[[Category: Gilley J]]
-[[Category: Bosanac, T]]
+[[Category: Gu W]]
-[[Category: Shi, Y]]
+[[Category: Horsefield S]]
-[[Category: Gilley, J]]
+[[Category: Hughes RO]]
-[[Category: Gu, W]]
+[[Category: Kobe B]]
-[[Category: Rank, M]]
+[[Category: Lai J]]
-[[Category: Staskawicz, B.J]]
+[[Category: Manik MK]]
+[[Category: Nanson JD]]
+[[Category: Rank M]]
+[[Category: Rathjen JP]]
+[[Category: Shi Y]]
+[[Category: Staskawicz BJ]]
+[[Category: Tiancong Q]]
+[[Category: Ve T]]
+[[Category: Williams SJ]]
+[[Category: Zhang X]]
+[[Category: Von Itzstein M]]

6o0r: Difference between revisions

Latest revision as of 14:49, 13 March 2024

Crystal structure of the TIR domain from human SARM1 in complex with glycerol

Structural highlights

Function

References

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