4d5n: Difference between revisions
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==Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state== | ==Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state== | ||
< | <SX load='4d5n' size='340' side='right' viewer='molstar' caption='[[4d5n]], [[Resolution|resolution]] 9.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4d5n]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4d5n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricket_paralysis_virus Cricket paralysis virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D5N FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d5n OCA], [https://pdbe.org/4d5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d5n RCSB], [https://www.ebi.ac.uk/pdbsum/4d5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d5n ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</ | </SX> | ||
[[Category: | [[Category: Cricket paralysis virus]] | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Hilal | [[Category: Hilal T]] | ||
[[Category: Mielke | [[Category: Mielke T]] | ||
[[Category: Muhs | [[Category: Muhs M]] | ||
[[Category: Pestova | [[Category: Pestova TV]] | ||
[[Category: Sanbonmatsu | [[Category: Sanbonmatsu KY]] | ||
[[Category: Skabkin | [[Category: Skabkin MA]] | ||
[[Category: Spahn | [[Category: Spahn CMT]] | ||
