6odc: Difference between revisions
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New page: '''Unreleased structure''' The entry 6odc is ON HOLD Authors: Zheng, X., Conti, C., Caravella, J., Zablocki, M.-M., Bair, K., Barczak, N., Han, B., Lancia Jr., D., Liu, C., Martin, M., ... |
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==Crystal structure of HDAC8 in complex with compound 30== | |||
<StructureSection load='6odc' size='340' side='right'caption='[[6odc]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6odc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ODC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=M7Y:(2E)-3-[2-(3-cyclopentyl-5,5-dimethyl-2-oxoimidazolidin-1-yl)phenyl]-N-hydroxyprop-2-enamide'>M7Y</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6odc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odc OCA], [https://pdbe.org/6odc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6odc RCSB], [https://www.ebi.ac.uk/pdbsum/6odc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6odc ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HDAC8_HUMAN HDAC8_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.<ref>PMID:10748112</ref> <ref>PMID:10926844</ref> <ref>PMID:10922473</ref> <ref>PMID:14701748</ref> | |||
==See Also== | |||
*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | |||
== References == | |||
[[ | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Barczak | [[Category: Large Structures]] | ||
[[Category: | [[Category: Bair K]] | ||
[[Category: | [[Category: Barczak N]] | ||
[[Category: | [[Category: Caravella J]] | ||
[[Category: | [[Category: Conti C]] | ||
[[Category: | [[Category: Garcia-Dancey R]] | ||
[[Category: | [[Category: Han B]] | ||
[[Category: | [[Category: Hardy C]] | ||
[[Category: | [[Category: Lahdenranta J]] | ||
[[Category: | [[Category: Lancia Jr D]] | ||
[[Category: Liu | [[Category: Leng C]] | ||
[[Category: | [[Category: Li P]] | ||
[[Category: | [[Category: Liu C]] | ||
[[Category: | [[Category: Martin M]] | ||
[[Category: | [[Category: Ng PY]] | ||
[[Category: Saldahna | [[Category: Pardo E]] | ||
[[Category: | [[Category: Rudnitskaya A]] | ||
[[Category: | [[Category: Saldahna A]] | ||
[[Category: | [[Category: Tan T]] | ||
[[Category: | [[Category: Thomason JJ]] | ||
[[Category: | [[Category: Toms AV]] | ||
[[Category: | [[Category: Yao L]] | ||
[[Category: Zablocki M-M]] | |||
[[Category: Zhang C]] | |||
[[Category: Zheng X]] | |||
Latest revision as of 07:08, 11 October 2023
Crystal structure of HDAC8 in complex with compound 30
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