5g47: Difference between revisions

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<StructureSection load='5g47' size='340' side='right'caption='[[5g47]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='5g47' size='340' side='right'caption='[[5g47]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5g47]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sfts_bunyavirus Sfts bunyavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G47 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5g47]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_fever_with_thrombocytopenia_syndrome_virus Severe fever with thrombocytopenia syndrome virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5G47 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g47 OCA], [http://pdbe.org/5g47 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g47 RCSB], [http://www.ebi.ac.uk/pdbsum/5g47 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g47 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5g47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g47 OCA], [https://pdbe.org/5g47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5g47 RCSB], [https://www.ebi.ac.uk/pdbsum/5g47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5g47 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GP_SFTS GP_SFTS] Structural component of the virion that interacts with glycoprotein C (By similarity). It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (By similarity). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after clathrin-mediated endocytosis of the virion (PubMed:23388721). Plays a role in the packaging of ribonucleoproteins during virus assembly (By similarity).[UniProtKB:P09613][UniProtKB:P21401]<ref>PMID:23388721</ref>  Structural component of the virion that interacts with glycoprotein N (By similarity). Acts as a class II fusion protein that is activated upon acidification and subsequent repositioning of the glycoprotein N (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (By similarity). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after clathrin-mediated endocytosis of the virion (PubMed:23388721).[UniProtKB:P09613][UniProtKB:P21401]<ref>PMID:23388721</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Sfts bunyavirus]]
[[Category: Severe fever with thrombocytopenia syndrome virus]]
[[Category: Behrens, A J]]
[[Category: Behrens AJ]]
[[Category: Bowden, T A]]
[[Category: Bowden TA]]
[[Category: Brennan, B]]
[[Category: Brennan B]]
[[Category: Crispin, M]]
[[Category: Crispin M]]
[[Category: Elliott, R M]]
[[Category: Elliott RM]]
[[Category: Halldorsson, S]]
[[Category: Halldorsson S]]
[[Category: Harlos, K]]
[[Category: Harlos K]]
[[Category: Huiskonen, J T]]
[[Category: Huiskonen JT]]
[[Category: Bunyavirus]]
[[Category: Class ii viral fusion]]
[[Category: Emerging virus]]
[[Category: Glycoprotein]]
[[Category: Huaiyangshan virus]]
[[Category: Phlebovirus]]
[[Category: Viral membrane fusion]]
[[Category: Viral protein]]
[[Category: Zoonosis]]
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