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<StructureSection load='4m80' size='340' side='right'caption='[[4m80]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
<StructureSection load='4m80' size='340' side='right'caption='[[4m80]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4m80]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canal Canal]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M80 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M80 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4m80]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M80 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cz1|1cz1]], [[4m81|4m81]], [[4m82|4m82]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.858&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CaO19.10507, XOG, XOG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m80 OCA], [https://pdbe.org/4m80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m80 RCSB], [https://www.ebi.ac.uk/pdbsum/4m80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m80 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucan_1,3-beta-glucosidase Glucan 1,3-beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.58 3.2.1.58] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m80 OCA], [http://pdbe.org/4m80 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m80 RCSB], [http://www.ebi.ac.uk/pdbsum/4m80 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m80 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/EXG1_CANAL EXG1_CANAL]] Major glucan 1,3-beta-glucosidase required for cell wall integrity. Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Can also function biosynthetically as a transglycosylase. Functions to deliver glucan from the cell to the extracellular matrix. Does not appear to impact cell wall glucan content of biofilm cells, nor is it necessary for filamentation or biofilm formation. Involved in cell-substrate and cell-cell adhesion. Adhesion to host-cell surfaces is the first critical step during mucosal infection. XOG1 is target of human antimicrobial peptide LL-37 for inhibition of cell adhesion.<ref>PMID:21713010</ref> <ref>PMID:22876186</ref>
[https://www.uniprot.org/uniprot/EXG1_CANAL EXG1_CANAL] Major glucan 1,3-beta-glucosidase required for cell wall integrity. Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Can also function biosynthetically as a transglycosylase. Functions to deliver glucan from the cell to the extracellular matrix. Does not appear to impact cell wall glucan content of biofilm cells, nor is it necessary for filamentation or biofilm formation. Involved in cell-substrate and cell-cell adhesion. Adhesion to host-cell surfaces is the first critical step during mucosal infection. XOG1 is target of human antimicrobial peptide LL-37 for inhibition of cell adhesion.<ref>PMID:21713010</ref> <ref>PMID:22876186</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Glucanase|Glucanase]]
*[[Glucanase 3D structures|Glucanase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Canal]]
[[Category: Candida albicans SC5314]]
[[Category: Glucan 1,3-beta-glucosidase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cutfield, J F]]
[[Category: Cutfield JF]]
[[Category: Cutfield, S M]]
[[Category: Cutfield SM]]
[[Category: Larsen, D S]]
[[Category: Larsen DS]]
[[Category: Nakatani, Y]]
[[Category: Nakatani Y]]
[[Category: Cell wall hydrolase]]
[[Category: Glycoside hydrolase]]
[[Category: Glycoside hydrolase family 5]]
[[Category: Glycosynthase]]
[[Category: Hydrolase]]
[[Category: Tim barrel]]
Retrieved from "https://proteopedia.org/4m80"