6jql: Difference between revisions
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==Structure of PaaZ, a bifunctional enzyme== | |||
<SX load='6jql' size='340' side='right' viewer='molstar' caption='[[6jql]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6jql]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JQL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jql OCA], [https://pdbe.org/6jql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jql RCSB], [https://www.ebi.ac.uk/pdbsum/6jql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jql ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Cannone | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/PAAZ_ECOLI PAAZ_ECOLI] Catalyzes the hydrolytic ring cleavage of 2-oxepin-2(3H)-ylideneacetyl-CoA (oxepin-CoA) via the open-chain aldehyde intermediate to yield 3-oxo-5,6-dehydrosuberyl-CoA. The enzyme consists of a C-terminal (R)-specific enoyl-CoA hydratase domain (formerly MaoC) that cleaves the ring and produces the highly reactive 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde and an N-terminal NADP-dependent aldehyde dehydrogenase domain that oxidizes the aldehyde to 3-oxo-5,6-dehydrosuberyl-CoA. Can also use crotonyl-CoA as substrate.<ref>PMID:20660314</ref> <ref>PMID:21296885</ref> <ref>PMID:9748275</ref> | ||
[[Category: | == References == | ||
[[Category: Sathyanarayanan | <references/> | ||
[[Category: Sowdhamini | __TOC__ | ||
[[Category: | </SX> | ||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Cannone G]] | |||
[[Category: Gakher L]] | |||
[[Category: Katagihallimath N]] | |||
[[Category: Sathyanarayanan N]] | |||
[[Category: Sowdhamini R]] | |||
[[Category: Vinothkumar KR]] | |||
Latest revision as of 10:39, 27 March 2024
Structure of PaaZ, a bifunctional enzyme
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