6ieb: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[6ieb]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IEB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6IEB FirstGlance]. <br>

<table><tr><td colspan='2'>[[6ieb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rift_Valley_fever_virus Rift Valley fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IEB FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ieb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ieb OCA], [~~http~~://pdbe.org/6ieb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ieb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ieb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ieb ProSAT]</span></td></tr>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.409Å</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ieb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ieb OCA], [https://pdbe.org/6ieb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ieb RCSB], [https://www.ebi.ac.uk/pdbsum/6ieb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ieb ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/GP_RVFV GP_RVFV] Structural component of the virion that interacts with glycoprotein C (By similarity). It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (PubMed:19193794, PubMed:23319635). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (By similarity). Plays a role in the packaging of ribonucleoproteins and polymerase during virus assembly (By similarity).[UniProtKB:P09613][UniProtKB:P21401]<ref>PMID:19193794</ref> <ref>PMID:23319635</ref> Structural component of the virion that interacts with glycoprotein N (By similarity). Acts as a class II fusion protein that is activated upon acidification and subsequent repositioning of the glycoprotein N (PubMed:23319635, PubMed:29097548). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (PubMed:19193794, PubMed:23319635). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (By similarity).[UniProtKB:P09613]<ref>PMID:19193794</ref> <ref>PMID:23319635</ref> <ref>PMID:29097548</ref> Plays a role for virus dissemination in the mosquito.[UniProtKB:P21401]<ref>PMID:24551252</ref> Plays a role for virus dissemination in mosquitoes.[UniProtKB:P21401]

== Publication Abstract from PubMed ==

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</div>

==See Also==

*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: ~~Gao, F~~]]

[[Category: Rift Valley fever virus]]

[[Category: Gao~~, G~~ F]]

[[Category: Gao F]]

[[Category: ~~Qi, J X~~]]

[[Category: Gao GF]]

[[Category: ~~Wang, Q H~~]]

[[Category: Qi JX]]

[[Category: ~~Wu, Y~~]]

[[Category: Wang QH]]

[[Category: ~~Antibody]]~~

[[Category: Wu Y]]

~~[[Category: Rvfv]]~~

~~[[Category: Structural protein]]~~

~~[[Category: Structural protein-immune system complex~~]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='6ieb' size='340' side='right'caption='[[6ieb]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6ieb]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IEB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6ieb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rift_Valley_fever_virus Rift Valley fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IEB FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ieb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ieb OCA], [http://pdbe.org/6ieb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ieb RCSB], [http://www.ebi.ac.uk/pdbsum/6ieb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ieb ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.409&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ieb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ieb OCA], [https://pdbe.org/6ieb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ieb RCSB], [https://www.ebi.ac.uk/pdbsum/6ieb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ieb ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/GP_RVFV GP_RVFV] Structural component of the virion that interacts with glycoprotein C (By similarity). It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (PubMed:19193794, PubMed:23319635). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (By similarity). Plays a role in the packaging of ribonucleoproteins and polymerase during virus assembly (By similarity).[UniProtKB:P09613][UniProtKB:P21401]<ref>PMID:19193794</ref> <ref>PMID:23319635</ref>   Structural component of the virion that interacts with glycoprotein N (By similarity). Acts as a class II fusion protein that is activated upon acidification and subsequent repositioning of the glycoprotein N (PubMed:23319635, PubMed:29097548). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (PubMed:19193794, PubMed:23319635). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (By similarity).[UniProtKB:P09613]<ref>PMID:19193794</ref> <ref>PMID:23319635</ref> <ref>PMID:29097548</ref>   Plays a role for virus dissemination in the mosquito.[UniProtKB:P21401]<ref>PMID:24551252</ref>   Plays a role for virus dissemination in mosquitoes.[UniProtKB:P21401]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 15: / Line 18: @@
 </div>
 <div class="pdbe-citations 6ieb" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Gao, F]]
+[[Category: Rift Valley fever virus]]
-[[Category: Gao, G F]]
+[[Category: Gao F]]
-[[Category: Qi, J X]]
+[[Category: Gao GF]]
-[[Category: Wang, Q H]]
+[[Category: Qi JX]]
-[[Category: Wu, Y]]
+[[Category: Wang QH]]
-[[Category: Antibody]]
+[[Category: Wu Y]]
-[[Category: Rvfv]]
-[[Category: Structural protein]]
-[[Category: Structural protein-immune system complex]]