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<StructureSection load='4msc' size='340' side='right'caption='[[4msc]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
<StructureSection load='4msc' size='340' side='right'caption='[[4msc]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4msc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MSC FirstGlance]. <br>
<table><tr><td colspan='2'>[[4msc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MSC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2ZT:2-[(QUINOLIN-7-YLOXY)METHYL]QUINOLINE'>2ZT</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mrw|4mrw]], [[4mrz|4mrz]], [[4ms0|4ms0]], [[4msa|4msa]], [[4mse|4mse]], [[4msh|4msh]], [[4msn|4msn]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2ZT:2-[(QUINOLIN-7-YLOXY)METHYL]QUINOLINE'>2ZT</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4msc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4msc OCA], [https://pdbe.org/4msc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4msc RCSB], [https://www.ebi.ac.uk/pdbsum/4msc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4msc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4msc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4msc OCA], [http://pdbe.org/4msc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4msc RCSB], [http://www.ebi.ac.uk/pdbsum/4msc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4msc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Phosphodiesterase|Phosphodiesterase]]
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Badger, J]]
[[Category: Badger J]]
[[Category: Chie-Leon, B]]
[[Category: Chie-Leon B]]
[[Category: Logan, C]]
[[Category: Logan C]]
[[Category: Nienaber, V]]
[[Category: Nienaber V]]
[[Category: Sridhar, V]]
[[Category: Sridhar V]]
[[Category: Fragment screening]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
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