5f2q: Difference between revisions
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<StructureSection load='5f2q' size='340' side='right'caption='[[5f2q]], [[Resolution|resolution]] 2.95Å' scene=''> | <StructureSection load='5f2q' size='340' side='right'caption='[[5f2q]], [[Resolution|resolution]] 2.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5f2q]] is a 10 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5f2q]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F2Q FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f2q OCA], [https://pdbe.org/5f2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f2q RCSB], [https://www.ebi.ac.uk/pdbsum/5f2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f2q ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/LECG_BOTJR LECG_BOTJR] Galactose-binding lectin which recognizes specific carbohydrate structures and agglutinates a variety of animal cells by binding to cell-surface glycoproteins and glycolipids. Calcium-dependent lectin. Shows high hemagglutinating activity. When injected into mouse hind paws, (10-100 ug/paw) causes edema and increases vascular permeability. In anesthetized rats, decreases the blood pressure by approximately 15%, with a rapid return to the resting level (PubMed:16309723). Is an effective inhibitor of cell growth in some cancer cell lines, especially against renal and pancreatic cancer cell lines, human breast and ovarian carcinoma, glioblastoma and a bovine brain microvascular endothelial cell line (PubMed:10628348, PubMed:11478954).<ref>PMID:10628348</ref> <ref>PMID:11478954</ref> <ref>PMID:16309723</ref> <ref>PMID:11902666</ref> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Bothrops jararacussu]] | [[Category: Bothrops jararacussu]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Nonato | [[Category: Nonato MC]] | ||
[[Category: Pinheiro MP]] | |||
[[Category: Pinheiro | [[Category: Sampaio SV]] | ||
[[Category: Sampaio | [[Category: Sartim MA]] | ||
[[Category: Sartim | [[Category: De Padua RAP]] | ||
[[Category: | |||
Latest revision as of 08:43, 12 July 2023
C-type lectin from Bothrops jararacussu
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