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==Ligand-triggered allosteric ADP release primes a plant NLR complex==
==Ligand-triggered allosteric ADP release primes a plant NLR complex==
<StructureSection load='6j5v' size='340' side='right'caption='[[6j5v]], [[Resolution|resolution]] 4.25&Aring;' scene=''>
<SX load='6j5v' size='340' side='right' viewer='molstar' caption='[[6j5v]], [[Resolution|resolution]] 4.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6j5v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J5V FirstGlance]. <br>
<table><tr><td colspan='2'>[[6j5v]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J5V FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BQL:[(2~{S})-2-azanyl-3-oxidanylidene-propyl]+[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl+hydrogen+phosphate'>BQL</scene>, <scene name='pdbligand=BQO:[(2~{R},3~{S})-3-azanyl-4-oxidanylidene-butan-2-yl]+[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl+hydrogen+phosphate'>BQO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.25&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RPP13L4, ZAR1, At3g50950, F18B3.230 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), PBL2, APK2A, KIN1, At1g14370, F14L17.14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), F15B8.100, Resistance related KinaSe 1, RKS1, At3g57710 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j5v OCA], [https://pdbe.org/6j5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j5v RCSB], [https://www.ebi.ac.uk/pdbsum/6j5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j5v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j5v OCA], [http://pdbe.org/6j5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j5v RCSB], [http://www.ebi.ac.uk/pdbsum/6j5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j5v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/R13L4_ARATH R13L4_ARATH]] CC-NB-LRR receptor-like protein required for recognition of the Pseudomonas syringae type III effector HopZ1a. Confers allele-specific recognition and virulence attenuation of HopZ1a. Immunity mediated by ZAR1 is independent of several genes required by other resistance protein signaling pathways such as NDR1 and RAR1.<ref>PMID:20368970</ref> [[http://www.uniprot.org/uniprot/PBL2_ARATH PBL2_ARATH]] Involved in disease resistance signaling (PubMed:20413097, PubMed:23951354). Contributes to pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) signaling and defense responses downstream of FLS2 (PubMed:20413097). Required for the bacterial XopAC/AvrAC effector-triggered immunity (ETI) against Xanthomonas campestris (PubMed:23951354).<ref>PMID:20413097</ref> <ref>PMID:23951354</ref> 
[https://www.uniprot.org/uniprot/R13L4_ARATH R13L4_ARATH] CC-NB-LRR receptor-like protein required for recognition of the Pseudomonas syringae type III effector HopZ1a. Confers allele-specific recognition and virulence attenuation of HopZ1a. Immunity mediated by ZAR1 is independent of several genes required by other resistance protein signaling pathways such as NDR1 and RAR1.<ref>PMID:20368970</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Arath]]
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Chai JJ]]
[[Category: Chai, J J]]
[[Category: Hu MJ]]
[[Category: Hu, M J]]
[[Category: Wang HW]]
[[Category: Wang, H W]]
[[Category: Wang J]]
[[Category: Wang, J]]
[[Category: Wang JZ]]
[[Category: Wang, J Z]]
[[Category: Zhou JM]]
[[Category: Zhou, J M]]
[[Category: Pbl2-ump]]
[[Category: Plant protein]]
[[Category: Rks1]]
[[Category: Zar1]]

Latest revision as of 08:04, 17 October 2024

Ligand-triggered allosteric ADP release primes a plant NLR complex

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