4q1b: Difference between revisions

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<StructureSection load='4q1b' size='340' side='right'caption='[[4q1b]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='4q1b' size='340' side='right'caption='[[4q1b]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4q1b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q1B FirstGlance]. <br>
<table><tr><td colspan='2'>[[4q1b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q1B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2Y0:N-(2-(3-(4-(((4,6-DIAMINOPYRIMIDIN-2-YL)THIO)METHYL)-5-PROPYLTHIAZOL-2-YL)PHENOXY)ETHYL)METHANESULFONAMIDE'>2Y0</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q18|4q18]], [[4q19|4q19]], [[4q1a|4q1a]], [[4q1c|4q1c]], [[4q1d|4q1d]], [[4q1e|4q1e]], [[4q1f|4q1f]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2Y0:N-(2-(3-(4-(((4,6-DIAMINOPYRIMIDIN-2-YL)THIO)METHYL)-5-PROPYLTHIAZOL-2-YL)PHENOXY)ETHYL)METHANESULFONAMIDE'>2Y0</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q1b OCA], [https://pdbe.org/4q1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q1b RCSB], [https://www.ebi.ac.uk/pdbsum/4q1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q1b ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q1b OCA], [http://pdbe.org/4q1b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q1b RCSB], [http://www.ebi.ac.uk/pdbsum/4q1b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q1b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
[https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Deoxycytidine kinase|Deoxycytidine kinase]]
*[[Deoxycytidine kinase 3D structures|Deoxycytidine kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Deoxycytidine kinase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lavie, A]]
[[Category: Lavie A]]
[[Category: Nomme, J]]
[[Category: Nomme J]]
[[Category: Deoxycytidine]]
[[Category: Inhibitor complex]]
[[Category: Kinase]]
[[Category: Phosphoryl transfer]]
[[Category: Phosphorylation]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]
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