4p8o: Difference between revisions

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<StructureSection load='4p8o' size='340' side='right'caption='[[4p8o]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4p8o' size='340' side='right'caption='[[4p8o]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4p8o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staa4 Staa4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P8O FirstGlance]. <br>
<table><tr><td colspan='2'>[[4p8o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_04-02981 Staphylococcus aureus 04-02981]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P8O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=883:1-ETHYL-3-[5-(5-FLUOROPYRIDIN-3-YL)-7-(PYRIMIDIN-2-YL)-1H-BENZIMIDAZOL-2-YL]UREA'>883</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gyrB, SAR0005 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=703339 STAA4])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=883:1-ETHYL-3-[5-(5-FLUOROPYRIDIN-3-YL)-7-(PYRIMIDIN-2-YL)-1H-BENZIMIDAZOL-2-YL]UREA'>883</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p8o OCA], [https://pdbe.org/4p8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p8o RCSB], [https://www.ebi.ac.uk/pdbsum/4p8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p8o ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p8o OCA], [http://pdbe.org/4p8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p8o RCSB], [http://www.ebi.ac.uk/pdbsum/4p8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p8o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GYRB_STAAR GYRB_STAAR]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]  
[https://www.uniprot.org/uniprot/GYRB_STAAR GYRB_STAAR] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Gyrase|Gyrase]]
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Staa4]]
[[Category: Staphylococcus aureus 04-02981]]
[[Category: Jacobs, M D]]
[[Category: Jacobs MD]]
[[Category: Antibacterial]]
[[Category: Gram-positive]]
[[Category: Gyrase]]
[[Category: Isomerase]]
[[Category: Staphylococcus aureus]]
[[Category: Topoisomerase]]
Retrieved from "https://proteopedia.org/4p8o"