4q18: Difference between revisions
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<StructureSection load='4q18' size='340' side='right'caption='[[4q18]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4q18' size='340' side='right'caption='[[4q18]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4q18]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4q18]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q18 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XJ:1-(5-(4-(((2,6-DIAMINOPYRIMIDIN-4-YL)THIO)METHYL)-5-PROPYLTHIAZOL-2-YL)-2-METHOXYPHENOXY)-2-METHYLPROPAN-2-OL'>2XJ</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2XJ:1-(5-(4-(((2,6-DIAMINOPYRIMIDIN-4-YL)THIO)METHYL)-5-PROPYLTHIAZOL-2-YL)-2-METHOXYPHENOXY)-2-METHYLPROPAN-2-OL'>2XJ</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q18 OCA], [https://pdbe.org/4q18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q18 RCSB], [https://www.ebi.ac.uk/pdbsum/4q18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q18 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 21: | ||
==See Also== | ==See Also== | ||
*[[Deoxycytidine kinase|Deoxycytidine kinase]] | *[[Deoxycytidine kinase 3D structures|Deoxycytidine kinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Lavie | [[Category: Lavie A]] | ||
[[Category: Nomme | [[Category: Nomme J]] | ||
Latest revision as of 17:26, 20 September 2023
Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 4 [1-[5-(4-{[(2,6-diaminopyrimidin-4-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]-2-methylpropan-2-ol]
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