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| '''Calpains''' (CAP) are calcium-dependent cysteine proteases. CAPs are regulated by Ca+2 concentration, phosphorylation and calpastatin.<ref>PMID:12843408</ref> The CAP family contains 14 members.<br /> | | '''Calpains''' (CAP) are calcium-dependent cysteine proteases. CAPs are regulated by Ca+2 concentration, phosphorylation and calpastatin.<ref>PMID:12843408</ref> The CAP family contains 14 members.<br /> |
| * '''CAP1''' (or mu-CAP) and '''CAP2''' (or M-CAP) T are the best characterized CAPs. <br /> | | * '''CAP1''' (or mu-CAP) and '''CAP2''' (or M-CAP) T are the best characterized CAPs. <br /> |
| | * '''CAP2''' limits the extent of neuronal plasticity and learning<ref>PMID:33339205</ref>. |
| | * '''CAP3''' is expressed in skeletal muscles and regulates sarcomere remodelling<ref>PMID:16884488</ref>. |
| * '''CAP7''' is atypical CAP that lacks a penta-EF-hand domain.<br /> | | * '''CAP7''' is atypical CAP that lacks a penta-EF-hand domain.<br /> |
| * '''CAP8''' and '''CAP9''' are involved in the mucosal defense against stress-induced gastropathies.<br /> | | * '''CAP8''' and '''CAP9''' are involved in the mucosal defense against stress-induced gastropathies.<br /> |
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| </StructureSection> | | </StructureSection> |
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| ==3D structures of calpain==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *CAP small subunit
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| **[[1aj5]]– rCAP domain VI – rat<br />
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| **[[1dvi]] - rCAP domain VI + Ca<br />
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| **[[1np8]] – rCAP residues 87-245 - Cd<br />
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| **[[1alv]], [[1nx2]] - pCAP domain VI + Ca – pig<br />
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| **[[1alw]], [[1nx3]] - pCAP domain VI + Ca+ inhibitor<br />
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| **[[1nx0]] - pCAP domain VI + Ca+ Calpastatin peptide + small molecule inhibitor peptide<br />
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| **[[1nx1]] - pCAP domain VI + Ca+ Calpastatin peptide<br />
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| **[[4phj]] – hCAP EF-hand subunit + Ca - human<br />
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| **[[4phk]], [[4phm]], [[4phn]], [[4wq2]], [[4wq3]], [[5d69]] – hCAP EF-hand subunit + Ca + inhibitor<br />
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| *CAP1
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| **[[1kxr]], [[1tlo]], [[1qxp]] - rCAP protease domain + Ca<br />
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| **[[1tl9]] - rCAP protease domain + Ca+ leupeptin inhibitor<br />
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| **[[2g8e]], [[2g8j]], [[2nqg]], [[2nqi]], [[2r9c]], [[2r9f]] - rCAP protease domain + Ca+ inhibitor<br />
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| **[[2ary]] - hCAP protease domain + Ca <br />
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| **[[1zcm]] - hCAP protease domain (mutant) + Ca+ inhibitor<br />
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| *CAP2
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| **[[1mdw]] – rCAP2 protease core domain I and II (mutant) + Ca<br />
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| **[[1df0]], [[1u5i]] – rCAP small subunit domain VI + rCAP2 large subunit<br />
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| **[[3df0]] - hCAP small subunit + hCAP2 large subunit + Calpastatin + Ca<br />
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| **[[3bow]] - rCAP small subunit + rCAP2 large subunit + Calpastatin + Ca<br />
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| **[[1kfu]], [[1kfx]] – hCAP small subunit + hCAP2 large subunit
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| *CAP3
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| **[[4okh]] - hCAP EF-hand domain residues 642-821<br />
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| **[[6bdt]], [[6bgp]] - hCAP residues 46-419 (mutant)<br />
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| **[[6bjd]] - hCAP residues 46-419 + sorbitol + guanidine derivative<br />
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| **[[6bkj]] - hCAP residues 46-419 + leupeptin peptide<br />
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| *CAP7
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| **[[2qfe]] - hCAP C2-like domain
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| *CAP8
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| **[[2nqa]] - hCAP protease domain + Ca+ leupeptin inhibitor<br />
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| *CAP9
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| **[[1ziv]] – hCAP catalytic domain<br />
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| **[[2p0r]] - hCAP protease domain + Ca+ leupeptin inhibitor<br />
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| *CAP13
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| **[[2i7a]] – hCAP domain IV + Ca<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
