6rbj: Difference between revisions
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==Crystal structure of KDM3B in complex with 5-(1H-tetrazol-5-yl)quinolin-8-ol== | |||
<StructureSection load='6rbj' size='340' side='right'caption='[[6rbj]], [[Resolution|resolution]] 2.09Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6rbj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RBJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.093Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JX8:5-(1~{H}-1,2,3,4-tetrazol-5-yl)quinolin-8-ol'>JX8</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rbj OCA], [https://pdbe.org/6rbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rbj RCSB], [https://www.ebi.ac.uk/pdbsum/6rbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rbj ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KDM3B_HUMAN KDM3B_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.<ref>PMID:16603237</ref> | |||
==See Also== | |||
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Arrowsmith | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Johansson | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: | [[Category: Edwards A]] | ||
[[Category: Schofield | [[Category: Johansson C]] | ||
[[Category: Kawamura A]] | |||
[[Category: Newman JA]] | |||
[[Category: Oppermann UCT]] | |||
[[Category: Schofield CJ]] | |||
Latest revision as of 12:18, 24 January 2024
Crystal structure of KDM3B in complex with 5-(1H-tetrazol-5-yl)quinolin-8-ol
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