|
|
| (9 intermediate revisions by the same user not shown) |
| Line 1: |
Line 1: |
| [[Image:1lbd.gif|left|200px]] | | #REDIRECT [[6hn6]] This PDB entry is obsolete and replaced by 6hn6 |
| | |
| <!--
| |
| The line below this paragraph, containing "STRUCTURE_1lbd", creates the "Structure Box" on the page.
| |
| You may change the PDB parameter (which sets the PDB file loaded into the applet)
| |
| or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
| |
| or leave the SCENE parameter empty for the default display.
| |
| -->
| |
| {{STRUCTURE_1lbd| PDB=1lbd | SCENE= }}
| |
| | |
| '''LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA'''
| |
| | |
| | |
| ==Overview==
| |
| The crystal structure of the human retinoid-X receptor RXR-alpha ligand-binding domain reveals a previously undiscovered fold of an antiparallel alpha-helical sandwich, packed as dimeric units. Two helices and one loop form the homodimerization surface, and hydrophobic heptad repeats participate in stabilizing the fold. The existence of a ligand-binding pocket is proposed that would allow 9-cis retinoic acid to interact with different functional modules, including the AF-2 activating domain. Several lines of evidence indicate that the overall structure is a prototype fold of ligand-binding domains of nuclear receptors.
| |
| | |
| ==About this Structure==
| |
| 1LBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBD OCA].
| |
| | |
| ==Reference==
| |
| Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha., Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D, Nature. 1995 Jun 1;375(6530):377-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7760929 7760929]
| |
| [[Category: Homo sapiens]]
| |
| [[Category: Single protein]]
| |
| [[Category: Bourguet, W.]]
| |
| [[Category: Moras, D.]]
| |
| [[Category: SPINE, Structural Proteomics in Europe.]]
| |
| [[Category: Nuclear receptor]]
| |
| [[Category: Spine]]
| |
| [[Category: Structural genomic]]
| |
| [[Category: Structural proteomics in europe]]
| |
| [[Category: Transcription factor]]
| |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:07:08 2008''
| |
