Chitinase: Difference between revisions

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== Function ==

[[Chitinase]]s cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. <ref>PMID:21054166</ref>

[[Chitinase]]s (Chi) cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. <ref>PMID:21054166</ref>.

* '''Chitinase I''' is found in plants.

* '''Chitinase II''' is found in plants, fungi and bacteria.

* '''Chitinase III''' has no sequence similarity to class I or II.

* '''Chitinase IV''' has similar characteristics to class I but are smaller than it.

==Disease ==

Chi is related to allergies and asthma.

Chi is related to allergies and asthma<ref>PMID:19295241</ref>.

== Structural highlights ==

The <scene name='27/271631/Cv/5'>chitin tetrasaccharide binding site</scene> of Chitinase A.<ref>PMID:24582745</ref>

The <scene name='27/271631/Cv/5'>chitin tetrasaccharide binding site</scene> of Chitinase A. <ref>PMID:24582745</ref> Water molecules are shown as red spheres.

== 3D Structures of Chitinase ==

Chitinase: Difference between revisions

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@@ Line 3: / Line 3: @@
 == Function ==
-[[Chitinase]]s cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. <ref>PMID:21054166</ref>
+[[Chitinase]]s (Chi) cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. <ref>PMID:21054166</ref>. <br />
+* '''Chitinase I''' is found in plants.<br />
+* '''Chitinase II''' is found in plants, fungi and bacteria.<br />
+* '''Chitinase III''' has no sequence similarity to class I or II.<br />
+* '''Chitinase IV''' has similar characteristics to class I but are smaller than it.<br />
 ==Disease ==
-Chi is related to allergies and asthma.
+Chi is related to allergies and asthma<ref>PMID:19295241</ref>.
 == Structural highlights ==
-The <scene name='27/271631/Cv/5'>chitin tetrasaccharide binding site</scene> of Chitinase A.<ref>PMID:24582745</ref>
+The <scene name='27/271631/Cv/5'>chitin tetrasaccharide binding site</scene> of Chitinase A. <ref>PMID:24582745</ref> Water molecules are shown as red spheres.
 == 3D Structures of Chitinase ==