6oqd: Difference between revisions
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New page: '''Unreleased structure''' The entry 6oqd is ON HOLD Authors: Huang, X. Description: Crystal structure of Mcl1 with inhibitor 8 Category: Unreleased Structures [[Category: Huang, X... |
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==Crystal structure of Mcl1 with inhibitor 8== | |||
<StructureSection load='6oqd' size='340' side='right'caption='[[6oqd]], [[Resolution|resolution]] 1.48Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6oqd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OQD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N0M:(4S,7aR,9aR,10S,15R)-6-chloro-10-hydroxy-15-methyl-3,4,7a,8,9,9a,10,11,12,13,14,15-dodecahydro-2H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1-naphthalene]-16,16,18(7H,17H)-trione'>N0M</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oqd OCA], [https://pdbe.org/6oqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oqd RCSB], [https://www.ebi.ac.uk/pdbsum/6oqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oqd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | |||
==See Also== | |||
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Huang | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Huang X]] | |||
Latest revision as of 14:52, 13 March 2024
Crystal structure of Mcl1 with inhibitor 8
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