6rjv: Difference between revisions
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New page: '''Unreleased structure''' The entry 6rjv is ON HOLD Authors: Merlino, A., Giorgio, A., Ferraro, G. Description: The X-ray structure of the Gold/Serum Albumin adduct obtained upon reac... |
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The | ==The X-ray structure of the Gold/Serum Albumin adduct obtained upon reaction of the protein with AuL12, a gold(III) dithiocarbamate complex== | ||
<StructureSection load='6rjv' size='340' side='right'caption='[[6rjv]], [[Resolution|resolution]] 3.21Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6rjv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RJV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.21Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rjv OCA], [https://pdbe.org/6rjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rjv RCSB], [https://www.ebi.ac.uk/pdbsum/6rjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rjv ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ALBU_BOVIN ALBU_BOVIN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The medicinal gold(III) dithiocarbamato complex AuL12 forms a stable adduct with bovine serum albumin. The crystal structure reveals that a single gold(I) center is bound to Cys34, with the dithiocarbamato ligand being released. To the best of our knowledge, this is the first structure for a gold adduct of serum albumin. | |||
Structural Characterization of a Gold/Serum Albumin Complex.,Pratesi A, Cirri D, Fregona D, Ferraro G, Giorgio A, Merlino A, Messori L Inorg Chem. 2019 Jul 30. doi: 10.1021/acs.inorgchem.9b01900. PMID:31361466<ref>PMID:31361466</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Ferraro | <div class="pdbe-citations 6rjv" style="background-color:#fffaf0;"></div> | ||
[[Category: | |||
[[Category: | ==See Also== | ||
*[[Albumin 3D structures|Albumin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bos taurus]] | |||
[[Category: Large Structures]] | |||
[[Category: Ferraro G]] | |||
[[Category: Giorgio A]] | |||
[[Category: Merlino A]] | |||
Latest revision as of 12:22, 24 January 2024
The X-ray structure of the Gold/Serum Albumin adduct obtained upon reaction of the protein with AuL12, a gold(III) dithiocarbamate complex
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